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Bupivacaine, epinephrine, dexamethasone, and clonidine
Bupivacaine, epinephrine, dexamethasone, and clonidine is a Local anesthetic combination with adjuvants Small molecule drug developed by Tufts Medical Center. It is currently in Phase 2 development for Regional anesthesia and analgesia (Phase 2 investigational). Also known as: Standard Preparation.
This combination provides local anesthesia via bupivacaine while epinephrine prolongs duration, dexamethasone reduces inflammation, and clonidine enhances analgesia through alpha-2 adrenergic receptor activation.
This combination provides local anesthesia via bupivacaine while epinephrine prolongs duration, dexamethasone reduces inflammation, and clonidine enhances analgesia through alpha-2 adrenergic receptor activation. Used for Regional anesthesia and analgesia (Phase 2 investigational).
At a glance
| Generic name | Bupivacaine, epinephrine, dexamethasone, and clonidine |
|---|---|
| Also known as | Standard Preparation |
| Sponsor | Tufts Medical Center |
| Drug class | Local anesthetic combination with adjuvants |
| Target | Voltage-gated sodium channels (bupivacaine); alpha-2 adrenergic receptors (clonidine); glucocorticoid receptor (dexamethasone) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Pain Management |
| Phase | Phase 2 |
Mechanism of action
Bupivacaine is a long-acting local anesthetic that blocks sodium channels in nerve fibers. Epinephrine causes vasoconstriction to prolong drug residence time at the injection site. Dexamethasone, a corticosteroid, reduces local inflammation and may extend anesthetic duration. Clonidine, an alpha-2 agonist, enhances analgesia and prolongs the sensory block when added to local anesthetics.
Approved indications
- Regional anesthesia and analgesia (Phase 2 investigational)
Common side effects
- Hypotension
- Bradycardia
- Dizziness
- Nausea
- Local injection site reactions
Key clinical trials
- Liposomal Bupivacaine vs Perineural Adjuvants in Adductor Canalf and iPACK Blocks in Total Knee Arthroplasty (PHASE4)
- RCT Comparing ESPB Solutions in Breast Surgery (PHASE2)
- Pecto-intercostal Fascial Block (PIFB) for Postop Analgesia Following Sternotomy in Cardiac Surgery Patients (PHASE4)
- Interscalene Block With Liposomal Bupivacaine vs. Interscalene Block With Bupivacaine and Adjuvants (PHASE4)
- Single Injection Adductor Canal Block Versus Continuous Adductor Canal Infusion for Total Knee Arthroplasty (EARLY_PHASE1)
- Dexamethasone Versus Local Infiltration Technique for Tonsillectomy in Children (NA)
- Protracted Effect of Combined Nerve Blocks After Total Knee Arthroplasty (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Bupivacaine, epinephrine, dexamethasone, and clonidine CI brief — competitive landscape report
- Bupivacaine, epinephrine, dexamethasone, and clonidine updates RSS · CI watch RSS
- Tufts Medical Center portfolio CI
Frequently asked questions about Bupivacaine, epinephrine, dexamethasone, and clonidine
What is Bupivacaine, epinephrine, dexamethasone, and clonidine?
How does Bupivacaine, epinephrine, dexamethasone, and clonidine work?
What is Bupivacaine, epinephrine, dexamethasone, and clonidine used for?
Who makes Bupivacaine, epinephrine, dexamethasone, and clonidine?
Is Bupivacaine, epinephrine, dexamethasone, and clonidine also known as anything else?
What drug class is Bupivacaine, epinephrine, dexamethasone, and clonidine in?
What development phase is Bupivacaine, epinephrine, dexamethasone, and clonidine in?
What are the side effects of Bupivacaine, epinephrine, dexamethasone, and clonidine?
What does Bupivacaine, epinephrine, dexamethasone, and clonidine target?
Related
- Drug class: All Local anesthetic combination with adjuvants drugs
- Target: All drugs targeting Voltage-gated sodium channels (bupivacaine); alpha-2 adrenergic receptors (clonidine); glucocorticoid receptor (dexamethasone)
- Manufacturer: Tufts Medical Center — full pipeline
- Therapeutic area: All drugs in Anesthesia/Pain Management
- Indication: Drugs for Regional anesthesia and analgesia (Phase 2 investigational)
- Also known as: Standard Preparation
- Compare: Bupivacaine, epinephrine, dexamethasone, and clonidine vs similar drugs
- Pricing: Bupivacaine, epinephrine, dexamethasone, and clonidine cost, discount & access