The Effect of Dexamethasone Versus Local Infiltration Technique on Postoperative Nausea and Vomiting After Tonsillectomy in Children: A Randomized Double-blind Clinical Trial

NCT02355678 NA COMPLETED

Tonsillectomy is one of the most frequent surgical operations performed in children \[1-4\]. It is usually associated with postoperative nausea and vomiting (PONV) with an incidence ranging from 23% to 73% \[2\]. Dexamethasone has been shown to be effective in reducing PONV after tonsillectomy using standardized anesthetic technique \[2, 5-7\]. Previous studies utilizing a different technique, the pre-incision infiltration of local anesthesia, had shown to decrease post-tonsillectomy pain, reduce analgesic consumption and provide a rapid return to normal activity \[8, 9\]. Given the effectiveness of dexamethasone and the pre-incision infiltration anesthetic technique, it would be beneficial to compare the effect of each on PONV.

Details

Lead sponsor	Makassed General Hospital
Phase	NA
Status	COMPLETED
Enrolment	129
Start date	2015-01
Completion	2015-08

Conditions

• Postoperative Nausea and Vomiting

Interventions

• dexamethasone
• Local anesthetic infiltration
• General anesthesia
• Tonsillectomy
• gastric content suction
• Tramadol hydrochloride
• Propacetamol hydrochloride
• Paracetamol Suppository

Primary outcomes

• Incidence of postoperative nausea and vomiting — 5 postoperative days
  incidence of early PONV in the post-anesthesia care unit (PACU) and late PONV on the floor and 5 days after discharge

Countries

Lebanon