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Bupivacaine and Fentanyl
Bupivacaine blocks sodium channels to provide local anesthesia, while fentanyl activates opioid receptors to provide analgesia, together delivering regional anesthesia and pain relief.
Bupivacaine blocks sodium channels to provide local anesthesia, while fentanyl activates opioid receptors to provide analgesia, together delivering regional anesthesia and pain relief. Used for Regional anesthesia and analgesia for surgical procedures, Epidural or spinal anesthesia with enhanced analgesia.
At a glance
| Generic name | Bupivacaine and Fentanyl |
|---|---|
| Also known as | Marcaine Spinal 0.5% Heavy, Fentanyl-Janssen |
| Sponsor | Bnai Zion Medical Center |
| Drug class | Local anesthetic with opioid analgesic combination |
| Target | Voltage-gated sodium channels (bupivacaine); mu-opioid receptor (fentanyl) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia and Pain Management |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine is a long-acting local anesthetic that inhibits sodium influx in nerve fibers, preventing action potential propagation and blocking sensory and motor transmission in a localized region. Fentanyl is a potent synthetic opioid agonist that binds to mu-opioid receptors in the central and peripheral nervous system to enhance analgesia. The combination provides synergistic anesthetic and analgesic effects for regional anesthesia procedures.
Approved indications
- Regional anesthesia and analgesia for surgical procedures
- Epidural or spinal anesthesia with enhanced analgesia
Common side effects
- Hypotension
- Bradycardia
- Nausea
- Respiratory depression
- Pruritus
- Urinary retention
Key clinical trials
- Parascapular Sub Iliocostalis Plane Block Versus Thoracic Paravertebral Plane Block for Traumatic Multiple Rib Fractures (NA)
- Intercostal Nerve Cryoablation Versus Epidural Analgesia for Nuss Repair of Pectus Excavatum (NA)
- Retrolaminar Block Versus Subcostal Transversus Abdominis Plane Block in Liver Resection Surgery (NA)
- Quality of Postoperative Analgesia and Functional Recovery After Elective Cesarean Delivery (NA)
- Intrathecal Hydromorphone vs Intrathecal Morphine to Treat Post Cesarean Pain in Patients With Opioid Use Disorder Taking Buprenorphine (PHASE4)
- Thoracic Epidural Analgesia or Four-Quadrant Transversus Abdominus Plane Block in Reducing Pain in Patients Undergoing Liver Surgery (PHASE3)
- Epidural vs. Dural Puncture Epidural in Labor Analgesia (NA)
- Maternal Satisfaction After Spinal Anesthesia for Cesarean Delivery
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Bupivacaine and Fentanyl CI brief — competitive landscape report
- Bupivacaine and Fentanyl updates RSS · CI watch RSS
- Bnai Zion Medical Center portfolio CI