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The combination provides synergistic anesthetic and analgesic effects for regional anesthesia procedures.","oneSentence":"Bupivacaine blocks sodium channels to provide local anesthesia, while fentanyl activates opioid receptors to provide analgesia, together delivering regional anesthesia and pain relief.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:40:56.710Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Regional anesthesia and analgesia for surgical procedures"},{"name":"Epidural or spinal anesthesia with enhanced analgesia"}]},"trialDetails":[{"nctId":"NCT07493473","phase":"NA","title":"Parascapular Sub Iliocostalis Plane Block Versus Thoracic Paravertebral Plane Block for Traumatic Multiple Rib Fractures","status":"ACTIVE_NOT_RECRUITING","sponsor":"Zagazig University","startDate":"2025-05-01","conditions":"Discitis of Thoracic Region","enrollment":36},{"nctId":"NCT05731973","phase":"NA","title":"Intercostal Nerve Cryoablation 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