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Bupivacaine 0.5% , Dexamethasone
Bupivacaine blocks sodium channels to provide local anesthesia, while dexamethasone reduces inflammation and swelling at the injection site.
Bupivacaine blocks sodium channels to provide local anesthesia, while dexamethasone reduces inflammation and swelling at the injection site. Used for Regional anesthesia and nerve blocks, Perioperative pain management, Local infiltration anesthesia.
At a glance
| Generic name | Bupivacaine 0.5% , Dexamethasone |
|---|---|
| Also known as | Dekort, Marcaine 0,5 % Injectable Solution |
| Sponsor | Sisli Hamidiye Etfal Training and Research Hospital |
| Drug class | Local anesthetic with corticosteroid adjuvant |
| Target | Voltage-gated sodium channels (bupivacaine); glucocorticoid receptor (dexamethasone) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia and Pain Management |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine is a long-acting local anesthetic that inhibits sodium influx into nerve fibers, preventing depolarization and blocking pain signal transmission. Dexamethasone, a corticosteroid, suppresses inflammatory responses and reduces edema, potentially prolonging anesthetic duration and improving pain control. This combination is used for regional anesthesia and pain management.
Approved indications
- Regional anesthesia and nerve blocks
- Perioperative pain management
- Local infiltration anesthesia
Common side effects
- Transient neurological symptoms
- Hypotension
- Bradycardia
- Allergic reactions
- Nerve injury
- Local tissue toxicity
Key clinical trials
- Postoperative Pain Monitoring With ANI in Lumbar Spine Surgery (NA)
- Pericapsular Nerve Group Block Versus Intrathecal Morphine for Analgesia After Total Hip Arthroplasty (NA)
- Dexmedetomidine and Dexamethasone Added as Adjuvant Infraclavicular Brachial Plexus Block in Upper Limb Surgery
- Genicular Nerve Block for Knee Pain in the ED (NA)
- Interscalene vs Phrenic-sparing Blocks in Obesity and Effect of Maximum Inspiratory Pressure (NA)
- Functional Endoscopic Sinus Surgery Study (PHASE1, PHASE2)
- HEIGHT-BASED AND CONVENTIONAL SPINAL ANAESTHETIC DOSING IN GERIATRIC PATIENTS (NA)
- Intrathecal Dexamethasone and Atropine on Morphine Induced Post-operative Nausea and Vomiting on Caesarean Section (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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