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Bupivacain (preoperative)
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. Used for Preoperative local and regional anesthesia, Infiltration anesthesia for surgical procedures, Nerve blocks and epidural anesthesia.
At a glance
| Generic name | Bupivacain (preoperative) |
|---|---|
| Also known as | Preoperative Fascia Iliaca Compartment Block |
| Sponsor | Başakşehir Çam & Sakura City Hospital |
| Drug class | Local anesthetic (amide class) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | Phase 3 |
Mechanism of action
Bupivacaine reversibly inhibits sodium influx into nerve fibers by binding to sodium channels from the intracellular side, thereby stabilizing the neuronal membrane and preventing depolarization. This results in a loss of sensation in the infiltrated tissue. It is commonly used for regional anesthesia and nerve blocks during surgical procedures.
Approved indications
- Preoperative local and regional anesthesia
- Infiltration anesthesia for surgical procedures
- Nerve blocks and epidural anesthesia
Common side effects
- Injection site reactions (pain, erythema)
- Systemic toxicity (CNS effects: tremor, seizures)
- Cardiovascular effects (hypotension, arrhythmias)
- Allergic reactions
Key clinical trials
- Cardiac Performance During Steep Trendelenburg Position in Patients Undergoing Robotic Surgery Surgery.
- The Effect of High-thoracic Erector Spinae Plane Block on Postoperative Pain and Diaphragmatic Function in Posterior Cervical Spine Surgery (PHASE3)
- Post-mastectomy Recovery: Comparing Preoperative PECS-II Blocks With Intraoperative Pectoral Blocks (PHASE4)
- The Effect of Fascia Iliaca Compartment Block (FICB) on QoR-15 Score in Partial Hip Arthroplasty Surgery (NA)
- Comparison of Paravertebral Block and Subcostal Transversus Abdominis Plane Block in Laparoscopic Nephrectomy (NA)
- Erector Spina Block or Parasternal Block Plus Chest Tube Wound Infiltration for Cardiac Surgeries (NA)
- Stellate Ganglion to Prevent Atrial Fibrillation (NA)
- Erector Spinae Plane Block for Postoperative Pain in Percutaneous Nephrolithotomy Patients: a Retrospective Study
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Bupivacain (preoperative) CI brief — competitive landscape report
- Bupivacain (preoperative) updates RSS · CI watch RSS
- Başakşehir Çam & Sakura City Hospital portfolio CI