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Botulinum Toxin Type A in saline water
Botulinum Toxin Type A in saline water is a Neurotoxin; Acetylcholine release inhibitor Small molecule drug developed by Helse Nord-Trøndelag HF. It is currently in Phase 3 development for Cervical dystonia, Blepharospasm, Hemifacial spasm. Also known as: Botox.
Botulinum toxin type A blocks acetylcholine release at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis.
Botulinum toxin type A blocks acetylcholine release at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis. Used for Cervical dystonia, Blepharospasm, Hemifacial spasm.
At a glance
| Generic name | Botulinum Toxin Type A in saline water |
|---|---|
| Also known as | Botox |
| Sponsor | Helse Nord-Trøndelag HF |
| Drug class | Neurotoxin; Acetylcholine release inhibitor |
| Target | SNAP-25 (synaptosome-associated protein of 25 kDa) |
| Modality | Small molecule |
| Therapeutic area | Neurology; Movement Disorders; Aesthetics |
| Phase | Phase 3 |
Mechanism of action
Botulinum toxin type A is a neurotoxin that irreversibly cleaves SNARE proteins (specifically SNAP-25) required for acetylcholine vesicle fusion and release at the neuromuscular junction. This results in temporary paralysis of injected muscles lasting 3-4 months. The toxin is formulated in saline for clinical administration and is used therapeutically to reduce muscle hyperactivity and associated symptoms in various conditions.
Approved indications
- Cervical dystonia
- Blepharospasm
- Hemifacial spasm
- Spasticity
- Chronic migraine
- Hyperhidrosis
Common side effects
- Muscle weakness or paralysis in unintended muscles
- Headache
- Neck pain
- Injection site pain or bruising
- Flu-like symptoms
- Ptosis (drooping eyelid)
Key clinical trials
- The Effectiveness of Guided Botulinum Toxin "A" Injection to the Masticatory Muscles in the Management of Condylar and Subcondylar Fractures (NA)
- Preoperative BOTOX® Injection for Large Ventral Hernia Repair (PHASE4)
- Botulinum Toxin A in Frequent and Chronic Tension-type Headache (PHASE3)
- Rectocele Repair with or Without Internal Sphincter Botulinum Toxin Injection: a Prospective Randomized Trial (PHASE4)
- "Follow the Sutures". A New Procedure for Injection of Botulinum Toxin for Chronic Migraine (PHASE2)
- Bladder Instillations Versus Onabotulinumtoxin A for Treatment of Interstitial Cystitis/Bladder Pain Syndrome (PHASE2)
- Investigation of Efficacy and Safety of Botulinum Toxin A (Botox-Allergan Inc) in Migraine Headaches (PHASE2, PHASE3)
- Botox Injection for Lower Extremity Lengthening and Deformity Correction Surgery (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Botulinum Toxin Type A in saline water CI brief — competitive landscape report
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- Helse Nord-Trøndelag HF portfolio CI
Frequently asked questions about Botulinum Toxin Type A in saline water
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Related
- Drug class: All Neurotoxin; Acetylcholine release inhibitor drugs
- Target: All drugs targeting SNAP-25 (synaptosome-associated protein of 25 kDa)
- Manufacturer: Helse Nord-Trøndelag HF — full pipeline
- Therapeutic area: All drugs in Neurology; Movement Disorders; Aesthetics
- Indication: Drugs for Cervical dystonia
- Indication: Drugs for Blepharospasm
- Indication: Drugs for Hemifacial spasm
- Also known as: Botox
- Compare: Botulinum Toxin Type A in saline water vs similar drugs
- Pricing: Botulinum Toxin Type A in saline water cost, discount & access