{"id":"botulinum-toxin-type-a-in-saline-water","safety":{"commonSideEffects":[{"rate":null,"effect":"Muscle weakness or paralysis in unintended muscles"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Neck pain"},{"rate":null,"effect":"Injection site pain or bruising"},{"rate":null,"effect":"Flu-like symptoms"},{"rate":null,"effect":"Ptosis (drooping eyelid)"}]},"_chembl":{"chemblId":"CHEMBL4297862","moleculeType":"Protein"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Botulinum toxin type A is a neurotoxin that irreversibly cleaves SNARE proteins (specifically SNAP-25) required for acetylcholine vesicle fusion and release at the neuromuscular junction. This results in temporary paralysis of injected muscles lasting 3-4 months. The toxin is formulated in saline for clinical administration and is used therapeutically to reduce muscle hyperactivity and associated symptoms in various conditions.","oneSentence":"Botulinum toxin type A blocks acetylcholine release at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:42:46.394Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cervical dystonia"},{"name":"Blepharospasm"},{"name":"Hemifacial spasm"},{"name":"Spasticity"},{"name":"Chronic migraine"},{"name":"Hyperhidrosis"}]},"trialDetails":[{"nctId":"NCT07374341","phase":"NA","title":"The Effectiveness of Guided Botulinum Toxin \"A\" Injection to the Masticatory Muscles in the Management of Condylar and Subcondylar Fractures","status":"RECRUITING","sponsor":"Pakinam Gheeta","startDate":"2025-04-10","conditions":"Condylar Fractures, Subcondylar Fracture","enrollment":16},{"nctId":"NCT07220382","phase":"PHASE4","title":"Preoperative BOTOX® Injection for Large Ventral Hernia Repair","status":"RECRUITING","sponsor":"The Cleveland Clinic","startDate":"2025-11-03","conditions":"Hernia Abdominal Wall, Botox Injection, Hernia Incisional Ventral","enrollment":188},{"nctId":"NCT04857671","phase":"PHASE3","title":"Botulinum Toxin A in Frequent and Chronic Tension-type Headache","status":"COMPLETED","sponsor":"Helse Nord-Trøndelag HF","startDate":"2022-10-03","conditions":"Tension-Type Headache","enrollment":66},{"nctId":"NCT06804993","phase":"PHASE4","title":"Rectocele Repair with or Without Internal Sphincter Botulinum Toxin Injection: a Prospective Randomized Trial","status":"ACTIVE_NOT_RECRUITING","sponsor":"Mansoura University","startDate":"2021-07-31","conditions":"Obstructed Defaecation Syndrome, Anterior Rectocele","enrollment":60},{"nctId":"NCT03543254","phase":"PHASE2","title":"\"Follow the Sutures\". A New Procedure for Injection of Botulinum Toxin for Chronic Migraine","status":"COMPLETED","sponsor":"Norwegian University of Science and Technology","startDate":"2018-05-01","conditions":"Migraine Disorders, Chronic Disease","enrollment":20},{"nctId":"NCT04401176","phase":"PHASE2","title":"Bladder Instillations Versus Onabotulinumtoxin A for Treatment of Interstitial Cystitis/Bladder Pain Syndrome","status":"COMPLETED","sponsor":"Walter Reed National Military Medical Center","startDate":"2020-09-15","conditions":"Interstitial Cystitis, Bladder Pain Syndrome","enrollment":58},{"nctId":"NCT00660192","phase":"PHASE2, PHASE3","title":"Investigation of Efficacy and Safety of Botulinum Toxin A (Botox-Allergan Inc) in Migraine Headaches","status":"COMPLETED","sponsor":"Yale University","startDate":"2008-01","conditions":"Refractory Migraine","enrollment":25},{"nctId":"NCT00412035","phase":"PHASE3","title":"Botox Injection for Lower Extremity Lengthening and Deformity Correction Surgery","status":"COMPLETED","sponsor":"Shriners Hospitals for Children","startDate":"2007-01","conditions":"Unequal Length of Limbs; Congenital, Lower Extremity Deformities, Congenital","enrollment":125},{"nctId":"NCT01167257","phase":"PHASE2","title":"Effects and Safety of Liposome Encapsulated Botulinum Toxin A for Overactive Bladder Syndrome","status":"COMPLETED","sponsor":"Buddhist Tzu Chi General Hospital","startDate":"2010-05","conditions":"Overactive Bladder","enrollment":62},{"nctId":"NCT01088230","phase":"PHASE1, PHASE2","title":"The Impact of Botox® During Robotic Rehabilitation of the Wrist Following Stroke","status":"COMPLETED","sponsor":"New York Presbyterian Hospital","startDate":"2009-06","conditions":"Stroke","enrollment":12}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Botox"],"phase":"phase_3","status":"active","brandName":"Botulinum Toxin Type A in saline water","genericName":"Botulinum Toxin Type A in saline water","companyName":"Helse Nord-Trøndelag HF","companyId":"helse-nord-tr-ndelag-hf","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Botulinum toxin type A blocks acetylcholine release at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis. Used for Cervical dystonia, Blepharospasm, Hemifacial spasm.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}