Last reviewed · How we verify
botulinum toxin Type A (32U)
Botulinum toxin Type A (32U) works by blocking the release of acetylcholine, a neurotransmitter that causes muscle contraction.
Botulinum toxin Type A (32U) works by blocking the release of acetylcholine, a neurotransmitter that causes muscle contraction. Used for Focal spasm of eyelid (blepharospasm), Strabismus, Cervical dystonia.
At a glance
| Generic name | botulinum toxin Type A (32U) |
|---|---|
| Also known as | BOTOX® |
| Sponsor | Allergan |
| Drug class | Neuromuscular blocking agent |
| Target | SNARE complex |
| Modality | Biologic |
| Therapeutic area | Neurology |
| Phase | Phase 3 |
Mechanism of action
This results in temporary muscle paralysis, which can be used to treat a variety of conditions, including muscle spasms, dystonia, and facial wrinkles. The toxin works by cleaving the SNARE complex, which is necessary for the release of acetylcholine from the presynaptic neuron.
Approved indications
- Focal spasm of eyelid (blepharospasm)
- Strabismus
- Cervical dystonia
- Hemifacial spasm
- Severe primary axillary hyperhidrosis
- Severe palmar hyperhidrosis
- Severe plantar hyperhidrosis
- Severe facial lines and wrinkles
Common side effects
- Dry mouth
- Eyelid swelling
- Headache
- Injection site pain
- Drooping eyelid (ptosis)
- Facial asymmetry
- Facial weakness
- Eye swelling
- Eye redness
- Eye irritation
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |