{"id":"botulinum-toxin-type-a-32u","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Dry mouth"},{"rate":"5-10%","effect":"Eyelid swelling"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-10%","effect":"Injection site pain"},{"rate":"1-5%","effect":"Drooping eyelid (ptosis)"},{"rate":"1-5%","effect":"Facial asymmetry"},{"rate":"1-5%","effect":"Facial weakness"},{"rate":"1-5%","effect":"Eye swelling"},{"rate":"1-5%","effect":"Eye redness"},{"rate":"1-5%","effect":"Eye irritation"}]},"_chembl":{"chemblId":"CHEMBL4297862","moleculeType":"Protein"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"This results in temporary muscle paralysis, which can be used to treat a variety of conditions, including muscle spasms, dystonia, and facial wrinkles. The toxin works by cleaving the SNARE complex, which is necessary for the release of acetylcholine from the presynaptic neuron.","oneSentence":"Botulinum toxin Type A (32U) works by blocking the release of acetylcholine, a neurotransmitter that causes muscle contraction.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:42:45.698Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Focal spasm of eyelid (blepharospasm)"},{"name":"Strabismus"},{"name":"Cervical dystonia"},{"name":"Hemifacial spasm"},{"name":"Severe primary axillary hyperhidrosis"},{"name":"Severe palmar hyperhidrosis"},{"name":"Severe plantar hyperhidrosis"},{"name":"Severe facial lines and wrinkles"}]},"trialDetails":[{"nctId":"NCT01797094","phase":"PHASE3","title":"BOTOX® in the Treatment of Upper Facial Lines in Japan","status":"COMPLETED","sponsor":"Allergan","startDate":"2013-02","conditions":"Upper Facial Rhytides, Crow's Feet Lines, Glabellar Lines","enrollment":101}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["BOTOX®"],"phase":"phase_3","status":"active","brandName":"botulinum toxin Type A (32U)","genericName":"botulinum toxin Type A (32U)","companyName":"Allergan","companyId":"allergan","modality":"Biologic","firstApprovalDate":"","aiSummary":"Botulinum toxin Type A (32U) works by blocking the release of acetylcholine, a neurotransmitter that causes muscle contraction. Used for Focal spasm of eyelid (blepharospasm), Strabismus, Cervical dystonia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}