Last reviewed 2026-04-22 · How we verify

Botox 100U

Botox (botulinum toxin type A) blocks acetylcholine release at the neuromuscular junction, causing temporary muscle paralysis.

Botox (botulinum toxin type A) blocks acetylcholine release at the neuromuscular junction, causing temporary muscle paralysis. Used for Cervical dystonia, Blepharospasm, Hemifacial spasm.

At a glance

Mechanism of action

Botulinum toxin type A cleaves SNARE proteins required for acetylcholine vesicle fusion and release at motor nerve terminals. This results in temporary flaccid paralysis of injected muscles, lasting 3-4 months. The effect is reversible as new neuromuscular junctions form over time.

Approved indications

• Cervical dystonia
• Blepharospasm
• Hemifacial spasm
• Strabismus
• Chronic migraine
• Overactive bladder
• Hyperhidrosis
• Glabellar lines and facial wrinkles (cosmetic)

Common side effects

• Headache
• Neck pain
• Injection site pain
• Muscle weakness
• Eyelid ptosis
• Diplopia
• Dry mouth

Key clinical trials

• Intradetrusor Botulinum Toxin A for OAB Via 1 Versus 10 Injections: A Randomized Clinical Trial (PHASE4)
• Role of Combination Therapy in Women With Refractory Overactive Bladder (NA)
• Feasibility of BOTOX Injection on Improving Female Stress Urinary Incontinence (EARLY_PHASE1)
• Treatment of Hypertrophic Scars Using Fractional CO2 Laser Alone in Comparison With Adding Botulinum Toxin Either Through Intralesional Injection or Assisted Drug Delivery (NA)
• Phase 1 Trial of JTM201 in Subjects With Post-stroke Upper Limb Spasticity (PHASE1)
• Evaluation the Efficacy of Zinc on Botulinum Toxin A Injection (NA)
• Intra Articular Injection of Botulinum Toxin Versus Corticoids in Gonarthrosis (PHASE2)
• Bladder Botox UTI Antibiotic Prophylaxis (PHASE4)

Primary sources

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