{"id":"botox-100u","safety":{"commonSideEffects":[{"rate":"5-15","effect":"Headache"},{"rate":"10-20","effect":"Neck pain"},{"rate":"5-10","effect":"Injection site pain"},{"rate":"5-15","effect":"Muscle weakness"},{"rate":"1-5","effect":"Eyelid ptosis"},{"rate":"1-3","effect":"Diplopia"},{"rate":"1-5","effect":"Dry mouth"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Botulinum toxin type A cleaves SNARE proteins required for acetylcholine vesicle fusion and release at motor nerve terminals. This results in temporary flaccid paralysis of injected muscles, lasting 3-4 months. The effect is reversible as new neuromuscular junctions form over time.","oneSentence":"Botox (botulinum toxin type A) blocks acetylcholine release at the neuromuscular junction, causing temporary muscle paralysis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:41:50.221Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cervical dystonia"},{"name":"Blepharospasm"},{"name":"Hemifacial spasm"},{"name":"Strabismus"},{"name":"Chronic migraine"},{"name":"Overactive bladder"},{"name":"Hyperhidrosis"},{"name":"Glabellar lines and facial wrinkles (cosmetic)"}]},"trialDetails":[{"nctId":"NCT05308979","phase":"PHASE4","title":"Intradetrusor Botulinum Toxin A for OAB Via 1 Versus 10 Injections: A Randomized Clinical Trial","status":"COMPLETED","sponsor":"University of California, Irvine","startDate":"2022-05-01","conditions":"Overactive Bladder, Urinary Urge Incontinence, Overactive Bladder Syndrome","enrollment":116},{"nctId":"NCT06438861","phase":"NA","title":"Role of Combination Therapy in Women With Refractory Overactive Bladder","status":"WITHDRAWN","sponsor":"University of Alabama at Birmingham","startDate":"2025-01-01","conditions":"Overactive Bladder Syndrome","enrollment":""},{"nctId":"NCT04984317","phase":"EARLY_PHASE1","title":"Feasibility of BOTOX Injection on Improving Female Stress Urinary Incontinence","status":"SUSPENDED","sponsor":"Northwell Health","startDate":"2022-02-14","conditions":"Stress Urinary Incontinence","enrollment":20},{"nctId":"NCT07360483","phase":"NA","title":"Treatment of Hypertrophic Scars Using Fractional CO2 Laser Alone in Comparison With Adding Botulinum Toxin Either Through Intralesional Injection or Assisted Drug Delivery","status":"COMPLETED","sponsor":"Cairo University","startDate":"2025-01-01","conditions":"Hypertrophic Scars","enrollment":48},{"nctId":"NCT07292025","phase":"PHASE1","title":"Phase 1 Trial of JTM201 in Subjects With Post-stroke Upper Limb Spasticity","status":"COMPLETED","sponsor":"Jetema Co., Ltd.","startDate":"2023-06-29","conditions":"Upper Limb Spasticity Post-Stroke","enrollment":30},{"nctId":"NCT07270042","phase":"NA","title":"Evaluation the Efficacy of Zinc on Botulinum Toxin A Injection","status":"NOT_YET_RECRUITING","sponsor":"Tishreen University","startDate":"2025-12-01","conditions":"Hyperactive Masseter Muscle","enrollment":20},{"nctId":"NCT03726788","phase":"PHASE2","title":"Intra Articular Injection of Botulinum Toxin Versus Corticoids in Gonarthrosis","status":"WITHDRAWN","sponsor":"Lille Catholic University","startDate":"2019-09","conditions":"Joint Diseases, Knee, Therapeutics","enrollment":""},{"nctId":"NCT06387329","phase":"PHASE4","title":"Bladder Botox UTI Antibiotic Prophylaxis","status":"RECRUITING","sponsor":"Walter Reed National Military Medical Center","startDate":"2024-04-04","conditions":"Overactive Bladder, Bladder Pain Syndrome","enrollment":100},{"nctId":"NCT06499324","phase":"PHASE3","title":"Surgery with Botulinum Toxin a for Incisional Hernia","status":"RECRUITING","sponsor":"Assistance Publique - 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Used for Cervical dystonia, Blepharospasm, Hemifacial spasm.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}