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Bicarbonate endovenous hydratation
Intravenous sodium bicarbonate administration increases serum bicarbonate levels to counteract metabolic acidosis and improve renal perfusion.
Intravenous sodium bicarbonate administration increases serum bicarbonate levels to counteract metabolic acidosis and improve renal perfusion. Used for Prevention of contrast-induced nephropathy in patients undergoing coronary angiography or other contrast procedures, Treatment of metabolic acidosis.
At a glance
| Generic name | Bicarbonate endovenous hydratation |
|---|---|
| Sponsor | David Garcia Cinca |
| Drug class | Electrolyte/alkalizing agent |
| Modality | Small molecule |
| Therapeutic area | Nephrology |
| Phase | Phase 3 |
Mechanism of action
Bicarbonate endovenous hydration works by replenishing bicarbonate ions in the bloodstream, which neutralizes excess hydrogen ions and restores acid-base balance. This intervention is particularly used to prevent contrast-induced nephropathy by alkalinizing urine and reducing oxidative stress in the renal tubules, while simultaneously providing volume expansion to maintain renal perfusion.
Approved indications
- Prevention of contrast-induced nephropathy in patients undergoing coronary angiography or other contrast procedures
- Treatment of metabolic acidosis
Common side effects
- Hypernatremia
- Hypokalemia
- Alkalosis
- Fluid overload
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Bicarbonate endovenous hydratation CI brief — competitive landscape report
- Bicarbonate endovenous hydratation updates RSS · CI watch RSS
- David Garcia Cinca portfolio CI