{"id":"bicarbonate-endovenous-hydratation","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypernatremia"},{"rate":null,"effect":"Hypokalemia"},{"rate":null,"effect":"Alkalosis"},{"rate":null,"effect":"Fluid overload"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bicarbonate endovenous hydration works by replenishing bicarbonate ions in the bloodstream, which neutralizes excess hydrogen ions and restores acid-base balance. This intervention is particularly used to prevent contrast-induced nephropathy by alkalinizing urine and reducing oxidative stress in the renal tubules, while simultaneously providing volume expansion to maintain renal perfusion.","oneSentence":"Intravenous sodium bicarbonate administration increases serum bicarbonate levels to counteract metabolic acidosis and improve renal perfusion.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:04:19.064Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of contrast-induced nephropathy in patients undergoing coronary angiography or other contrast procedures"},{"name":"Treatment of metabolic acidosis"}]},"trialDetails":[{"nctId":"NCT02872155","phase":"PHASE3","title":"Comparative Study of the Efficacy of Oral Versus Intravenous Hydration as a Preventive Measure of Contrast-induced Nephropathy (CIN) in Patients With Renal Insufficiency (RI) Grade III Under Study Conducting Computed Tomography (CT)","status":"COMPLETED","sponsor":"David Garcia Cinca","startDate":"2017-07-04","conditions":"Renal Insufficiency","enrollment":264}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Bicarbonate endovenous hydratation","genericName":"Bicarbonate endovenous hydratation","companyName":"David Garcia Cinca","companyId":"david-garcia-cinca","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Intravenous sodium bicarbonate administration increases serum bicarbonate levels to counteract metabolic acidosis and improve renal perfusion. Used for Prevention of contrast-induced nephropathy in patients undergoing coronary angiography or other contrast procedures, Treatment of metabolic acidosis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}