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Benzoyl peroxide 5% gel

University of Southern California · FDA-approved active Small molecule

Benzoyl peroxide 5% gel is a Topical antimicrobial and keratolytic agent Small molecule drug developed by University of Southern California. It is currently FDA-approved for Acne vulgaris (mild to moderate).

Benzoyl peroxide kills acne-causing bacteria and promotes skin cell turnover by generating reactive oxygen species.

Benzoyl peroxide kills acne-causing bacteria and promotes skin cell turnover by generating reactive oxygen species. Used for Acne vulgaris (mild to moderate).

At a glance

Generic nameBenzoyl peroxide 5% gel
SponsorUniversity of Southern California
Drug classTopical antimicrobial and keratolytic agent
ModalitySmall molecule
Therapeutic areaDermatology
PhaseFDA-approved

Mechanism of action

Benzoyl peroxide is a potent oxidizing agent that penetrates the skin and decomposes to produce oxygen radicals, which are bactericidal against Cutibacterium acnes (formerly Propionibacterium acnes). It also has keratolytic properties that help shed dead skin cells and reduce comedone formation. The 5% concentration provides a balance between efficacy and tolerability for topical acne treatment.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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Frequently asked questions about Benzoyl peroxide 5% gel

What is Benzoyl peroxide 5% gel?

Benzoyl peroxide 5% gel is a Topical antimicrobial and keratolytic agent drug developed by University of Southern California, indicated for Acne vulgaris (mild to moderate).

How does Benzoyl peroxide 5% gel work?

Benzoyl peroxide kills acne-causing bacteria and promotes skin cell turnover by generating reactive oxygen species.

What is Benzoyl peroxide 5% gel used for?

Benzoyl peroxide 5% gel is indicated for Acne vulgaris (mild to moderate).

Who makes Benzoyl peroxide 5% gel?

Benzoyl peroxide 5% gel is developed and marketed by University of Southern California (see full University of Southern California pipeline at /company/university-of-southern-california).

What drug class is Benzoyl peroxide 5% gel in?

Benzoyl peroxide 5% gel belongs to the Topical antimicrobial and keratolytic agent class. See all Topical antimicrobial and keratolytic agent drugs at /class/topical-antimicrobial-and-keratolytic-agent.

What development phase is Benzoyl peroxide 5% gel in?

Benzoyl peroxide 5% gel is FDA-approved (marketed).

What are the side effects of Benzoyl peroxide 5% gel?

Common side effects of Benzoyl peroxide 5% gel include Skin irritation and erythema, Dryness and peeling, Contact dermatitis, Bleaching of hair or fabrics.

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