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Belladonna and Opium Suppositories
Belladonna and Opium Suppositories is a Anticholinergic/opioid combination Small molecule drug developed by Kristina A. Butler. It is currently FDA-approved for Rectal pain and spasm, Hemorrhoids, Post-anal surgical pain. Also known as: B & O Supprettes.
Belladonna alkaloids block muscarinic cholinergic receptors to reduce smooth muscle spasms, while opium alkaloids activate opioid receptors to provide analgesia and further reduce intestinal motility.
Belladonna alkaloids block muscarinic cholinergic receptors to reduce smooth muscle spasms, while opium alkaloids activate opioid receptors to provide analgesia and further reduce intestinal motility. Used for Rectal pain and spasm, Hemorrhoids, Post-anal surgical pain.
At a glance
| Generic name | Belladonna and Opium Suppositories |
|---|---|
| Also known as | B & O Supprettes |
| Sponsor | Kristina A. Butler |
| Drug class | Anticholinergic/opioid combination |
| Target | Muscarinic acetylcholine receptors; mu opioid receptors |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology |
| Phase | FDA-approved |
Mechanism of action
Belladonna (atropine and related tropane alkaloids) acts as an anticholinergic agent, inhibiting parasympathetic nervous system activity to relax smooth muscle in the gastrointestinal tract and reduce spasms. Opium alkaloids (primarily morphine and codeine) bind to mu and other opioid receptors in the central and peripheral nervous system, providing pain relief and reducing intestinal secretions and motility. Together, these agents address both pain and spasm associated with rectal and anal conditions.
Approved indications
- Rectal pain and spasm
- Hemorrhoids
- Post-anal surgical pain
Common side effects
- Dry mouth
- Constipation
- Drowsiness
- Dizziness
- Urinary retention
Key clinical trials
- The Use of Belladonna and Opium Suppository in the Treatment of Postoperative Stent Pain (PHASE4)
- Effects of Perioperative B&O Suppositories on Post-op Pain and Morphine Use After Laparoscopic Prostatectomy (NA)
- B&O for TLH Post-operative Pain and Nausea (PHASE4)
- Timing of B and O Suppositories to Help Relieve Post-operative Bladder Spasms (PHASE4)
- Assessing Maternal Post-partum Pain With Suppositories (PHASE4)
- Effect of an Anti-spasmodic Suppository to Improve Comfort After Urologic Surgery (NA)
- Postoperative Belladonna and Morphine Suppositories in Vaginal Surgery (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Belladonna and Opium Suppositories CI brief — competitive landscape report
- Belladonna and Opium Suppositories updates RSS · CI watch RSS
- Kristina A. Butler portfolio CI
Frequently asked questions about Belladonna and Opium Suppositories
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Related
- Drug class: All Anticholinergic/opioid combination drugs
- Target: All drugs targeting Muscarinic acetylcholine receptors; mu opioid receptors
- Manufacturer: Kristina A. Butler — full pipeline
- Therapeutic area: All drugs in Gastroenterology
- Indication: Drugs for Rectal pain and spasm
- Indication: Drugs for Hemorrhoids
- Indication: Drugs for Post-anal surgical pain
- Also known as: B & O Supprettes