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Balanced hydroxyethyl starch solution
Balanced hydroxyethyl starch solution acts as a volume expander that restores and maintains circulating blood volume in patients with acute blood loss or hypovolemia.
Balanced hydroxyethyl starch solution acts as a volume expander that restores and maintains circulating blood volume in patients with acute blood loss or hypovolemia. Used for Acute blood loss and hypovolemia requiring volume replacement in perioperative and critical care settings.
At a glance
| Generic name | Balanced hydroxyethyl starch solution |
|---|---|
| Also known as | Tetraspan |
| Sponsor | Rambam Health Care Campus |
| Drug class | Synthetic colloid / volume expander |
| Modality | Small molecule |
| Therapeutic area | Critical Care / Acute Medicine |
| Phase | FDA-approved |
Mechanism of action
Hydroxyethyl starch (HES) is a synthetic colloid derived from amylopectin that remains in the intravascular space longer than crystalloid solutions, providing sustained plasma volume expansion. The 'balanced' formulation typically refers to a solution with electrolyte composition and pH designed to minimize metabolic acidosis and electrolyte disturbances compared to unbalanced HES products. It is used as a blood volume substitute in acute care settings to maintain hemodynamic stability and tissue perfusion.
Approved indications
- Acute blood loss and hypovolemia requiring volume replacement in perioperative and critical care settings
Common side effects
- Acute kidney injury
- Coagulopathy / increased bleeding
- Hyperchloremic acidosis
- Anaphylactic reactions
Key clinical trials
- Hydroxyethyl Starch Versus Crystalloid and Postoperative Major Adverse Kidney Complications (PHASE4)
- The Influence of Fluid Removal Using Continuous Venovenous Hemofiltration (CVVH) on Intra-abdominal Pressure and Kidney Function (PHASE3)
- Comparison of Minimal Versus Conventional Extracorporeal Circulation in Coronary Surgery (NA)
- Colloids in Pediatric Cardiac Surgery: Comparison Between a Balanced and a Non-balanced Colloid (PHASE3)
- Plasma Volume Replacement (PVR) Therapy With Colloid and Crystalloid Solutions (PHASE4)
- Hypertonic Saline-hetastarch in Cardiac Surgery (PHASE4)
- HES and Acute Kidney Injury in Adult Cardiac Surgery
- KOREAN Enhanced RecOvery Strategy for Colorectal Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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