{"id":"balanced-hydroxyethyl-starch-solution","safety":{"commonSideEffects":[{"rate":null,"effect":"Acute kidney injury"},{"rate":null,"effect":"Coagulopathy / increased bleeding"},{"rate":null,"effect":"Hyperchloremic acidosis"},{"rate":null,"effect":"Anaphylactic reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Hydroxyethyl starch (HES) is a synthetic colloid derived from amylopectin that remains in the intravascular space longer than crystalloid solutions, providing sustained plasma volume expansion. The 'balanced' formulation typically refers to a solution with electrolyte composition and pH designed to minimize metabolic acidosis and electrolyte disturbances compared to unbalanced HES products. It is used as a blood volume substitute in acute care settings to maintain hemodynamic stability and tissue perfusion.","oneSentence":"Balanced hydroxyethyl starch solution acts as a volume expander that restores and maintains circulating blood volume in patients with acute blood loss or hypovolemia.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:28:12.941Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute blood loss and hypovolemia requiring volume replacement in perioperative and critical care settings"}]},"trialDetails":[{"nctId":"NCT07410988","phase":"PHASE4","title":"Hydroxyethyl Starch Versus Crystalloid and Postoperative Major Adverse Kidney Complications","status":"NOT_YET_RECRUITING","sponsor":"Seoul National University Hospital","startDate":"2026-04-01","conditions":"Cardiac Surgery","enrollment":1292},{"nctId":"NCT01077895","phase":"PHASE3","title":"The Influence of Fluid Removal Using Continuous Venovenous Hemofiltration (CVVH) on Intra-abdominal Pressure and Kidney Function","status":"WITHDRAWN","sponsor":"University Hospital, Ghent","startDate":"2010-02","conditions":"Critically Ill, Intra-Abdominal Hypertension, Abdominal Compartment Syndrome","enrollment":""},{"nctId":"NCT01603589","phase":"NA","title":"Comparison of Minimal Versus Conventional Extracorporeal Circulation in Coronary Surgery","status":"COMPLETED","sponsor":"AHEPA University Hospital","startDate":"2009-01","conditions":"Coronary Artery Bypass","enrollment":150},{"nctId":"NCT02584868","phase":"PHASE3","title":"Colloids in Pediatric Cardiac Surgery: Comparison Between a Balanced and a Non-balanced Colloid","status":"COMPLETED","sponsor":"Queen Fabiola Children's University Hospital","startDate":"2013-02-15","conditions":"Cardiac Surgery, Cardiopulmonary Bypass","enrollment":88},{"nctId":"NCT01117649","phase":"PHASE4","title":"Plasma Volume Replacement (PVR) Therapy With Colloid and Crystalloid Solutions","status":"COMPLETED","sponsor":"B. 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Used for Acute blood loss and hypovolemia requiring volume replacement in perioperative and critical care settings.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}