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B (Clorhexidine 2%)
Chlorhexidine is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, leading to rapid bactericidal and bacteriostatic effects.
Chlorhexidine is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, leading to rapid bactericidal and bacteriostatic effects. Used for Oral antisepsis and plaque control, Skin antisepsis and wound disinfection, Mucous membrane disinfection.
At a glance
| Generic name | B (Clorhexidine 2%) |
|---|---|
| Also known as | Clorhexidine 2% |
| Sponsor | Instituto de Investigacion Sanitaria La Fe |
| Drug class | Antimicrobial agent / Antiseptic |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease / Antisepsis |
| Phase | FDA-approved |
Mechanism of action
Chlorhexidine works by binding to and disrupting the cell membranes of microorganisms, causing leakage of cellular contents and protein denaturation. At higher concentrations it is bactericidal (kills bacteria), while at lower concentrations it can be bacteriostatic (inhibits growth). It is effective against a wide range of gram-positive and gram-negative bacteria, as well as some fungi and viruses.
Approved indications
- Oral antisepsis and plaque control
- Skin antisepsis and wound disinfection
- Mucous membrane disinfection
Common side effects
- Tooth staining
- Taste alteration
- Oral irritation
- Allergic contact dermatitis
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |