{"id":"b-clorhexidine-2","safety":{"commonSideEffects":[{"rate":null,"effect":"Tooth staining"},{"rate":null,"effect":"Taste alteration"},{"rate":null,"effect":"Oral irritation"},{"rate":null,"effect":"Allergic contact dermatitis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Chlorhexidine works by binding to and disrupting the cell membranes of microorganisms, causing leakage of cellular contents and protein denaturation. At higher concentrations it is bactericidal (kills bacteria), while at lower concentrations it can be bacteriostatic (inhibits growth). It is effective against a wide range of gram-positive and gram-negative bacteria, as well as some fungi and viruses.","oneSentence":"Chlorhexidine is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, leading to rapid bactericidal and bacteriostatic effects.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:20:24.567Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Oral antisepsis and plaque control"},{"name":"Skin antisepsis and wound disinfection"},{"name":"Mucous membrane disinfection"}]},"trialDetails":[{"nctId":"NCT03489512","phase":"PHASE4","title":"Comparison Trial for Chloraprep Versus Aqueous Chlorhexidine (2%) for the Prevention of Catheter-related Bacteremia","status":"WITHDRAWN","sponsor":"Instituto de Investigacion Sanitaria La Fe","startDate":"2019-10-01","conditions":"Sepsis Affecting Skin, Central Venous Catheter Related Bacteremia","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Clorhexidine 2%"],"phase":"marketed","status":"active","brandName":"B (Clorhexidine 2%)","genericName":"B (Clorhexidine 2%)","companyName":"Instituto de Investigacion Sanitaria La Fe","companyId":"instituto-de-investigacion-sanitaria-la-fe","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Chlorhexidine is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, leading to rapid bactericidal and bacteriostatic effects. Used for Oral antisepsis and plaque control, Skin antisepsis and wound disinfection, Mucous membrane disinfection.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}