Last reviewed 2026-04-22 · How we verify

Azithromycin + Artesunate

Azithromycin and artesunate work synergistically to inhibit bacterial protein synthesis and parasitic hemozoin formation, respectively, with potential immunomodulatory effects.

Azithromycin and artesunate work synergistically to inhibit bacterial protein synthesis and parasitic hemozoin formation, respectively, with potential immunomodulatory effects. Used for Malaria (investigational combination therapy), Bacterial and parasitic co-infections (investigational).

At a glance

Mechanism of action

Azithromycin is a macrolide antibiotic that inhibits bacterial 50S ribosomal subunit function, while artesunate is an artemisinin derivative that generates reactive oxygen species and inhibits hemozoin polymerization in parasites. The combination may exploit complementary antimicrobial and anti-inflammatory mechanisms, potentially enhancing efficacy against certain infections or inflammatory conditions.

Approved indications

• Malaria (investigational combination therapy)
• Bacterial and parasitic co-infections (investigational)

Common side effects

• Gastrointestinal disturbance (nausea, diarrhea)
• Headache
• Abdominal pain
• QT prolongation (azithromycin-related)

Key clinical trials

• Azithromycin + Artesunate v Artemether-lumefantrine in Uncomplicated Malaria. (PHASE3)
• Chloroquine Alone or in Combination for Malaria in Children in Malawi (PHASE3)
• Azithromycin Combination Therapy for the Treatment of Severe Malaria (PHASE2)
• Azithromycin Combination Therapy for the Treatment of Uncomplicated Falciparum Malaria in Bangladesh (PHASE2)
• Azithromycin Combination Therapy for Malaria (PHASE2)
• Efficacy and Safety of Azithromycin and Artesunate in Pregnant Women (NA)

Primary sources

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