{"id":"azithromycin-artesunate","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbance (nausea, diarrhea)"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"QT prolongation (azithromycin-related)"}]},"_chembl":{"chemblId":"CHEMBL361497","moleculeType":"Small molecule","molecularWeight":"384.43"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Azithromycin is a macrolide antibiotic that inhibits bacterial 50S ribosomal subunit function, while artesunate is an artemisinin derivative that generates reactive oxygen species and inhibits hemozoin polymerization in parasites. The combination may exploit complementary antimicrobial and anti-inflammatory mechanisms, potentially enhancing efficacy against certain infections or inflammatory conditions.","oneSentence":"Azithromycin and artesunate work synergistically to inhibit bacterial protein synthesis and parasitic hemozoin formation, respectively, with potential immunomodulatory effects.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:03:17.646Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Malaria (investigational combination therapy)"},{"name":"Bacterial and parasitic co-infections (investigational)"}]},"trialDetails":[{"nctId":"NCT00694694","phase":"PHASE3","title":"Azithromycin + Artesunate v Artemether-lumefantrine in Uncomplicated Malaria.","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2008-06","conditions":"Malaria","enrollment":261},{"nctId":"NCT00379821","phase":"PHASE3","title":"Chloroquine Alone or in Combination for Malaria in Children in Malawi","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2007-02","conditions":"Plasmodium Falciparum Infection","enrollment":640},{"nctId":"NCT01374126","phase":"PHASE2","title":"Azithromycin Combination Therapy for the Treatment of Severe Malaria","status":"COMPLETED","sponsor":"Medical University of Vienna","startDate":"2011-07","conditions":"Falciparum Malaria","enrollment":75},{"nctId":"NCT00356005","phase":"PHASE2","title":"Azithromycin Combination Therapy for the Treatment of Uncomplicated Falciparum Malaria in Bangladesh","status":"COMPLETED","sponsor":"Medical University of Vienna","startDate":"2006-08","conditions":"Uncomplicated Falciparum Malaria","enrollment":228},{"nctId":"NCT00299208","phase":"PHASE2","title":"Azithromycin Combination Therapy for Malaria","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"Plasmodium Falciparum Malaria","enrollment":120},{"nctId":"NCT00287300","phase":"NA","title":"Efficacy and Safety of Azithromycin and Artesunate in Pregnant Women","status":"COMPLETED","sponsor":"University of North Carolina","startDate":"2003-09","conditions":"Malaria","enrollment":141}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["zithromax"],"phase":"phase_3","status":"active","brandName":"Azithromycin + Artesunate","genericName":"Azithromycin + Artesunate","companyName":"Medical University of Vienna","companyId":"medical-university-of-vienna","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Azithromycin and artesunate work synergistically to inhibit bacterial protein synthesis and parasitic hemozoin formation, respectively, with potential immunomodulatory effects. Used for Malaria (investigational combination therapy), Bacterial and parasitic co-infections (investigational).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}