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Autologous Bone Marrow Aspirate Concentrate
Autologous bone marrow aspirate concentrate delivers a patient's own bone marrow-derived cells (including mesenchymal stem cells and hematopoietic progenitors) to promote tissue repair and reduce inflammation.
Autologous bone marrow aspirate concentrate delivers a patient's own bone marrow-derived cells (including mesenchymal stem cells and hematopoietic progenitors) to promote tissue repair and reduce inflammation. Used for Orthopedic injuries and degenerative joint disease (Phase 3 development), Musculoskeletal tissue repair.
At a glance
| Generic name | Autologous Bone Marrow Aspirate Concentrate |
|---|---|
| Also known as | BMAC |
| Sponsor | CELL Technologies Inc. |
| Drug class | Cell therapy; autologous stem cell product |
| Modality | Biologic |
| Therapeutic area | Regenerative Medicine; Orthopedics; Musculoskeletal |
| Phase | Phase 3 |
Mechanism of action
The product is prepared by aspirating bone marrow from the patient, concentrating the nucleated cell fraction, and reinjecting it into damaged tissue. The mechanism relies on the regenerative and immunomodulatory properties of bone marrow stem cells, which can differentiate into tissue-specific cells, secrete anti-inflammatory cytokines, and promote angiogenesis. This autologous approach avoids immune rejection and leverages the body's own repair mechanisms.
Approved indications
- Orthopedic injuries and degenerative joint disease (Phase 3 development)
- Musculoskeletal tissue repair
Common side effects
- Injection site pain or swelling
- Infection at aspiration or injection site
- Transient increase in local inflammation
Key clinical trials
- Biologic Injection For Adults With Lumbar Disc Herniation (NA)
- Using Autologous Bone Marrow Cells With Wharton Gel Exosomes to Stimulate Hepatic Cell Repair in Liver Cirrhosis (NA)
- HyaloFAST Trial for Repair of Articular Cartilage in the Knee (NA)
- CAM Procedure With BMAC for Shoulder OA (PHASE1)
- Biologic Augmentation With Mesenchymal Stem Cells in Patients Undergoing Anterior Cruciate Ligament Reconstruction (NA)
- Autologous Bone Marrow Aspirate Treatment for Early-Stage Osteonecrosis (NA)
- Concentrated Bone Marrow Aspirate in Revision ACL Reconstruction (PHASE4)
- Stem Cells vs. Steroids for Discogenic Back Pain (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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