{"id":"autologous-bone-marrow-aspirate-concentrate","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain or swelling"},{"rate":null,"effect":"Infection at aspiration or injection site"},{"rate":null,"effect":"Transient increase in local inflammation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The product is prepared by aspirating bone marrow from the patient, concentrating the nucleated cell fraction, and reinjecting it into damaged tissue. The mechanism relies on the regenerative and immunomodulatory properties of bone marrow stem cells, which can differentiate into tissue-specific cells, secrete anti-inflammatory cytokines, and promote angiogenesis. This autologous approach avoids immune rejection and leverages the body's own repair mechanisms.","oneSentence":"Autologous bone marrow aspirate concentrate delivers a patient's own bone marrow-derived cells (including mesenchymal stem cells and hematopoietic progenitors) to promote tissue repair and reduce inflammation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:03:05.069Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Orthopedic injuries and degenerative joint disease (Phase 3 development)"},{"name":"Musculoskeletal tissue repair"}]},"trialDetails":[{"nctId":"NCT07386548","phase":"NA","title":"Biologic Injection For Adults With Lumbar Disc Herniation","status":"NOT_YET_RECRUITING","sponsor":"Weill Medical College of Cornell University","startDate":"2026-02-01","conditions":"Degenerative Disc Disease, DDD, Degenerative Disc Disease Lumbar","enrollment":90},{"nctId":"NCT07374185","phase":"NA","title":"Using Autologous Bone Marrow Cells With Wharton Gel Exosomes to Stimulate Hepatic Cell Repair in Liver Cirrhosis","status":"NOT_YET_RECRUITING","sponsor":"Global Stem Cell Center, Baghdad","startDate":"2026-02-20","conditions":"Liver Cirrhosis","enrollment":10},{"nctId":"NCT02659215","phase":"NA","title":"HyaloFAST Trial for Repair of Articular Cartilage in the Knee","status":"ACTIVE_NOT_RECRUITING","sponsor":"Anika Therapeutics, Inc.","startDate":"2015-12","conditions":"Defect of Articular Cartilage","enrollment":200},{"nctId":"NCT04826224","phase":"PHASE1","title":"CAM Procedure With BMAC for Shoulder OA","status":"TERMINATED","sponsor":"Shane A. 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