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ASU
ASU (avocado-soybean unsaponifiables) is a plant extract that reduces inflammatory mediators and inhibits cartilage degradation in osteoarthritis.
ASU (avocado-soybean unsaponifiables) is a plant extract that reduces inflammatory mediators and inhibits cartilage degradation in osteoarthritis. Used for Osteoarthritis of the knee and hip.
At a glance
| Generic name | ASU |
|---|---|
| Sponsor | Laboratoires Expanscience S.A. |
| Drug class | Plant-derived anti-inflammatory agent |
| Modality | Small molecule |
| Therapeutic area | Rheumatology / Orthopedics |
| Phase | FDA-approved |
Mechanism of action
ASU is a mixture of unsaponifiable fractions derived from avocado and soybean oils that modulates inflammatory pathways, particularly reducing IL-6, IL-8, and TNF-α production. It inhibits matrix metalloproteinases and other enzymes responsible for cartilage breakdown, while promoting cartilage repair mechanisms. The extract also has antioxidant properties that may protect joint tissues from oxidative stress.
Approved indications
- Osteoarthritis of the knee and hip
Common side effects
- Gastrointestinal upset
- Nausea
- Diarrhea
- Abdominal discomfort
Key clinical trials
- Ambulatory Stroke Unit Treatment for Elderly Patients (NA)
- Descriptive Observational Study of Patient-performed Pre-oxygenation
- Implication of Long Non-coding RNA HOTTIP Haplotype on Liver Cancer Metastasis
- Back to ECE Safely With SAGE: Reducing COVID-19 Transmission in Hispanic and Low-income Preschoolers (NA)
- The RolE of Prolonged Nightly faSTing to Improve Sleep and cOgnition in bREast Cancer Survivors (NA)
- A Before and After Study Studying the Impact of an Analgesia Protocol After Discharge From Outpatient Surgery
- Measurement Training and Feedback System: Family-Based Services (NA)
- Investigating the Feasibility and Preliminary Effects of Yoga on Excessive Gestational Weight Gain (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- ASU CI brief — competitive landscape report
- ASU updates RSS · CI watch RSS
- Laboratoires Expanscience S.A. portfolio CI