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Artemether-lumefantrine combination plus albendazole
This combination kills malaria parasites through artemether's rapid parasite clearance and lumefantrine's sustained blood schizonticide activity, while albendazole eliminates co-occurring helminth infections.
This combination kills malaria parasites through artemether's rapid parasite clearance and lumefantrine's sustained blood schizonticide activity, while albendazole eliminates co-occurring helminth infections. Used for Uncomplicated malaria (Plasmodium falciparum) with concurrent helminth infection, Malaria and soil-transmitted helminth co-infections in endemic regions.
At a glance
| Generic name | Artemether-lumefantrine combination plus albendazole |
|---|---|
| Sponsor | Navrongo Health Research Centre, Ghana |
| Drug class | Antimalarial combination with anthelmintic |
| Target | Plasmodium falciparum (multiple mechanisms); Ascaris, Hookworm, Trichuris (tubulin) |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | FDA-approved |
Mechanism of action
Artemether is a fast-acting artemisinin derivative that rapidly reduces parasite biomass by generating reactive oxygen species within infected red blood cells. Lumefantrine provides sustained antimalarial activity by inhibiting parasite heme polymerization. Albendazole is a broad-spectrum anthelmintic that disrupts microtubule formation in helminths, addressing the common co-infection of malaria and intestinal worms in endemic populations.
Approved indications
- Uncomplicated malaria (Plasmodium falciparum) with concurrent helminth infection
- Malaria and soil-transmitted helminth co-infections in endemic regions
Common side effects
- Nausea
- Vomiting
- Abdominal pain
- Diarrhea
- Headache
- Dizziness
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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