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Arm 2. Iodophor/CHG Decolonization
Iodophor and chlorhexidine gluconate (CHG) work together to reduce pathogenic bacteria colonization on skin through antimicrobial activity.
Iodophor and chlorhexidine gluconate (CHG) work together to reduce pathogenic bacteria colonization on skin through antimicrobial activity. Used for Skin decolonization to reduce surgical site infections, Reduction of pathogenic skin colonization in hospitalized patients.
At a glance
| Generic name | Arm 2. Iodophor/CHG Decolonization |
|---|---|
| Sponsor | Harvard Pilgrim Health Care |
| Drug class | Topical antimicrobial/antiseptic combination |
| Modality | Small molecule |
| Therapeutic area | Infection Prevention |
| Phase | FDA-approved |
Mechanism of action
Iodophor is an iodine-based antiseptic that disrupts bacterial cell membranes and protein synthesis, while CHG is a broad-spectrum antimicrobial that damages bacterial cell walls and membranes. Together, they are used for skin decolonization to reduce the burden of pathogenic organisms (particularly Staphylococcus aureus) on the skin surface before surgical procedures or in hospitalized patients at risk for infection.
Approved indications
- Skin decolonization to reduce surgical site infections
- Reduction of pathogenic skin colonization in hospitalized patients
Common side effects
- Skin irritation or contact dermatitis
- Allergic reaction (iodine sensitivity)
- Local erythema
Key clinical trials
- Mupirocin-Iodophor ICU Decolonization Swap Out Trial (PHASE4)
- Project PROTECT: Protecting Nursing Homes From Infections and Hospitalization (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Arm 2. Iodophor/CHG Decolonization CI brief — competitive landscape report
- Arm 2. Iodophor/CHG Decolonization updates RSS · CI watch RSS
- Harvard Pilgrim Health Care portfolio CI