{"id":"arm-2-iodophor-chg-decolonization","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation or contact dermatitis"},{"rate":null,"effect":"Allergic reaction (iodine sensitivity)"},{"rate":null,"effect":"Local erythema"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Iodophor is an iodine-based antiseptic that disrupts bacterial cell membranes and protein synthesis, while CHG is a broad-spectrum antimicrobial that damages bacterial cell walls and membranes. Together, they are used for skin decolonization to reduce the burden of pathogenic organisms (particularly Staphylococcus aureus) on the skin surface before surgical procedures or in hospitalized patients at risk for infection.","oneSentence":"Iodophor and chlorhexidine gluconate (CHG) work together to reduce pathogenic bacteria colonization on skin through antimicrobial activity.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:42:42.136Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Skin decolonization to reduce surgical site infections"},{"name":"Reduction of pathogenic skin colonization in hospitalized patients"}]},"trialDetails":[{"nctId":"NCT03140423","phase":"PHASE4","title":"Mupirocin-Iodophor ICU Decolonization Swap Out Trial","status":"COMPLETED","sponsor":"Harvard Pilgrim Health Care","startDate":"2017-05-01","conditions":"Staphylococcus Aureus","enrollment":353323},{"nctId":"NCT03118232","phase":"PHASE4","title":"Project PROTECT: Protecting Nursing Homes From Infections and Hospitalization","status":"COMPLETED","sponsor":"University of California, Irvine","startDate":"2017-04-03","conditions":"Hospitalization, Infection","enrollment":13952}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Arm 2. Iodophor/CHG Decolonization","genericName":"Arm 2. Iodophor/CHG Decolonization","companyName":"Harvard Pilgrim Health Care","companyId":"harvard-pilgrim-health-care","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Iodophor and chlorhexidine gluconate (CHG) work together to reduce pathogenic bacteria colonization on skin through antimicrobial activity. Used for Skin decolonization to reduce surgical site infections, Reduction of pathogenic skin colonization in hospitalized patients.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}