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Application of Carnoy solution
Carnoy solution is a fixative and tissue-hardening agent used in surgical and pathological applications to preserve and harden tissue specimens.
Carnoy solution is a fixative and tissue-hardening agent used in surgical and pathological applications to preserve and harden tissue specimens. Used for Tissue fixation and hardening in endoscopic sinus surgery, Tumor bed treatment and margin control in surgical oncology, Hemostasis and tissue preservation in otolaryngological procedures.
At a glance
| Generic name | Application of Carnoy solution |
|---|---|
| Sponsor | University of Belgrade |
| Modality | Small molecule |
| Therapeutic area | Oncology, Surgery |
| Phase | FDA-approved |
Mechanism of action
Carnoy solution is a chemical fixative composed of ethanol, chloroform, and acetic acid that rapidly penetrates and fixes tissue by denaturing proteins and removing lipids. It is primarily used in surgical oncology and otolaryngology to chemically cauterize and harden tissue margins, particularly in endoscopic sinus surgery and tumor bed treatment. The solution acts as both a fixative for histopathological examination and a tissue-hardening agent to reduce bleeding and improve surgical visualization.
Approved indications
- Tissue fixation and hardening in endoscopic sinus surgery
- Tumor bed treatment and margin control in surgical oncology
- Hemostasis and tissue preservation in otolaryngological procedures
Common side effects
- Tissue irritation and chemical burn
- Mucosal damage
- Postoperative pain
Key clinical trials
- Usage of 5-fluorouracil and Carnoy's Solution in Surgical Treatment of Odontogenic Keratocysts (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Application of Carnoy solution CI brief — competitive landscape report
- Application of Carnoy solution updates RSS · CI watch RSS
- University of Belgrade portfolio CI