Last reviewed · How we verify
Antithyroid Drug
Antithyroid Drug is a Antithyroid agent Small molecule drug developed by Seoul St. Mary's Hospital. It is currently in Phase 3 development for Hyperthyroidism / Graves' disease. Also known as: Thiamazol, Propylthiouracil.
Antithyroid drugs inhibit thyroid peroxidase and reduce thyroid hormone synthesis to treat hyperthyroidism.
Antithyroid drugs are small molecule medications used to treat conditions such as thyroid dysfunction, hypothyroidism, and hyperthyroidism. They are often used in combination with other treatments, including thyroid hormone replacement therapy like levothyroxine.
-
Baseline phase 3 → approval rate
+58.3pp
Industry-wide phase 3 drugs reach approval ~58.3% of the time (BIO/Informa 2023 industry benchmark across all therapeutic areas).
| Regulator | Country | Likely year | Lag vs FDA |
|---|---|---|---|
| FDA | US | 2028–2030 | — |
| EMA | EU | 2029–2031 | +0.7 yr |
| MHRA | GB | 2029–2031 | +0.7 yr |
| Health Canada | CA | 2029–2032 | +0.9 yr |
| TGA | AU | 2029–2032 | +1.2 yr |
| PMDA | JP | 2029–2032 | +1.5 yr |
| NMPA | CN | 2030–2033 | +2.3 yr |
| MFDS | KR | 2029–2032 | +1.4 yr |
| CDSCO | IN | 2029–2033 | +1.8 yr |
| ANVISA | BR | 2030–2033 | +2.3 yr |
Hover any row for the lag rationale. Lag estimates are reduced when the drug has FDA Breakthrough or EMA PRIME designation (sponsors file globally in parallel).
Estimate based on the BIO/Informa industry phase transition rates plus per-drug modifiers for therapeutic area, sponsor type, FDA designations, mechanism, and trial design. Per-jurisdiction lags from Tufts CSDD international approval studies. Not investment, clinical or regulatory advice. Methodology: /methodology#likelihood.
At a glance
| Generic name | Antithyroid Drug |
|---|---|
| Also known as | Thiamazol, Propylthiouracil |
| Sponsor | Seoul St. Mary's Hospital |
| Drug class | Antithyroid agent |
| Target | Thyroid peroxidase (TPO) |
| Modality | Small molecule |
| Therapeutic area | Endocrinology |
| Phase | Phase 3 |
Mechanism of action
Antithyroid agents block the enzyme thyroid peroxidase, which is essential for incorporating iodine into thyroid hormones (T3 and T4). By inhibiting this enzyme, these drugs decrease the production and release of excess thyroid hormones, thereby reducing the metabolic effects of hyperthyroidism. Common agents in this class include propylthiouracil (PTU) and methimazole.
Approved indications
- Hyperthyroidism / Graves' disease
Common side effects
- Agranulocytosis
- Rash
- Hepatotoxicity
- Arthralgia
Key clinical trials
- A Study to Assess the Efficacy, Safety, and Tolerability of IMVT-1402 as Treatment for Adult Participants With Graves' Disease (PHASE2)
- A Long-Term Extension Study of IMVT-1402 in Adult Participants With Graves' Disease (GD) (PHASE2)
- Levothyroxine Intervention in Pregnant Women with TSH （2.5 MIU/L-upper Limit of Reference Range） and Negative Thyroid Peroxidase Antibody (PHASE4)
- Thyroid Function and Autoimmunity in Subfertility Women and Assisted Reproductive Therapy
- TSH Suppression During Radiotherapy on Thyroid Site to Prevent Iatrogenic Hypothyroidism in Pediatric Cancer Patients (PHASE3)
- A Conservative vs an Ablative Approach for Treatment of Hyperthyroidism in Patients With Graves' Orbitopathy (PHASE3)
- TSI and Its Relationship With Graves' Disease Relapse
- Change of Gut Microbiome in the Treatment of Graves' Disease
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Antithyroid Drug CI brief — competitive landscape report
- Antithyroid Drug updates RSS · CI watch RSS
- Seoul St. Mary's Hospital portfolio CI
Frequently asked questions about Antithyroid Drug
What is Antithyroid Drug?
How does Antithyroid Drug work?
What is Antithyroid Drug used for?
Who makes Antithyroid Drug?
Is Antithyroid Drug also known as anything else?
What drug class is Antithyroid Drug in?
What development phase is Antithyroid Drug in?
What are the side effects of Antithyroid Drug?
What does Antithyroid Drug target?
Related
- Drug class: All Antithyroid agent drugs
- Target: All drugs targeting Thyroid peroxidase (TPO)
- Manufacturer: Seoul St. Mary's Hospital — full pipeline
- Therapeutic area: All drugs in Endocrinology
- Indication: Drugs for Hyperthyroidism / Graves' disease
- Also known as: Thiamazol, Propylthiouracil
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing