{"id":"antithyroid-drug","safety":{"commonSideEffects":[{"rate":"0.1–0.5","effect":"Agranulocytosis"},{"rate":"1–5","effect":"Rash"},{"rate":"0.1–1","effect":"Hepatotoxicity"},{"rate":"1–5","effect":"Arthralgia"}]},"_chembl":{"chemblId":"CHEMBL157030","moleculeType":"Small molecule","molecularWeight":"883.99"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Antithyroid agents block the enzyme thyroid peroxidase, which is essential for incorporating iodine into thyroid hormones (T3 and T4). By inhibiting this enzyme, these drugs decrease the production and release of excess thyroid hormones, thereby reducing the metabolic effects of hyperthyroidism. Common agents in this class include propylthiouracil (PTU) and methimazole.","oneSentence":"Antithyroid drugs inhibit thyroid peroxidase and reduce thyroid hormone synthesis to treat hyperthyroidism.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:01:57.938Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hyperthyroidism / Graves' disease"}]},"trialDetails":[{"nctId":"NCT07018323","phase":"PHASE2","title":"A Study to Assess the Efficacy, Safety, and Tolerability of IMVT-1402 as Treatment for Adult Participants With Graves' Disease","status":"RECRUITING","sponsor":"Immunovant Sciences GmbH","startDate":"2025-06-19","conditions":"Graves' Disease","enrollment":210},{"nctId":"NCT07286006","phase":"PHASE2","title":"A Long-Term Extension Study of IMVT-1402 in Adult Participants With Graves' Disease (GD)","status":"ENROLLING_BY_INVITATION","sponsor":"Immunovant Sciences GmbH","startDate":"2026-01-26","conditions":"Graves' Disease","enrollment":372},{"nctId":"NCT06653907","phase":"PHASE4","title":"Levothyroxine Intervention in Pregnant Women with TSH （2.5 MIU/L-upper Limit of Reference Range） and Negative Thyroid Peroxidase Antibody","status":"NOT_YET_RECRUITING","sponsor":"Yang ZHANG","startDate":"2024-10-25","conditions":"Thyroid Abnormalities, Pregnant Woman, Pregnancy Outcomes","enrollment":400},{"nctId":"NCT06394466","phase":"","title":"Thyroid Function and Autoimmunity in Subfertility Women and Assisted Reproductive Therapy","status":"COMPLETED","sponsor":"Rio de Janeiro State University","startDate":"2021-07-01","conditions":"Ovarian Failure, Thyroid Diseases","enrollment":453},{"nctId":"NCT05316922","phase":"PHASE3","title":"TSH Suppression During Radiotherapy on Thyroid Site to Prevent Iatrogenic Hypothyroidism in Pediatric Cancer Patients","status":"RECRUITING","sponsor":"Fondazione IRCCS Istituto Nazionale dei Tumori, Milano","startDate":"2021-12-13","conditions":"Hypothyroidism; Irradiation","enrollment":68},{"nctId":"NCT04776993","phase":"PHASE3","title":"A Conservative vs an Ablative Approach for Treatment of Hyperthyroidism in Patients With Graves' Orbitopathy","status":"UNKNOWN","sponsor":"University of Pisa","startDate":"2023-03-02","conditions":"Graves' Orbitopathy","enrollment":52},{"nctId":"NCT05713097","phase":"","title":"TSI and Its Relationship With Graves' Disease Relapse","status":"COMPLETED","sponsor":"University of Medicine and Pharmacy at Ho Chi Minh City","startDate":"2022-01-02","conditions":"Graves Disease, Immunoglobulin, Anti-Thyroid Antibodies Disorder","enrollment":352},{"nctId":"NCT04383795","phase":"","title":"Change of Gut Microbiome in the Treatment of Graves' Disease","status":"COMPLETED","sponsor":"Seoul St. Mary's Hospital","startDate":"2020-05-19","conditions":"Graves' Disease","enrollment":29},{"nctId":"NCT05385029","phase":"","title":"Fetal and Neonatal Thyroid in Pregnancies With Severe Acute Respiratory Syndrome Coronavirus 2 ( SARS- COV2 ) COVID-19","status":"COMPLETED","sponsor":"OMER B ABDELBASIT","startDate":"2020-05-01","conditions":"Thyroid Dysfunction, Hypothyroidism, Hyperthyroidism","enrollment":95},{"nctId":"NCT05043233","phase":"","title":"Observation in the Treatment of Graves' Disease","status":"UNKNOWN","sponsor":"Shanghai Jiao Tong University School of Medicine","startDate":"2020-10-01","conditions":"Patient Acceptance of Health Care","enrollment":1000},{"nctId":"NCT01945229","phase":"","title":"Thumb-ECG Ambulant Screening for Atrial Fibrillation in Patients Treated for Hyperthyroidism (TAMBOURINE)","status":"TERMINATED","sponsor":"Karolinska Institutet","startDate":"2014-02","conditions":"Hyperthyroidism, Atrial Fibrillation","enrollment":110},{"nctId":"NCT04433936","phase":"","title":"Corneal Tomographic Parameters in TGD","status":"COMPLETED","sponsor":"Ameera Gamal Abdelhameed","startDate":"2018-02-01","conditions":"Keratoconus, Corneal Ectasia, Thyroid Eye Disease","enrollment":100},{"nctId":"NCT04304794","phase":"","title":"Iodinated Contrast Media Induced Hyperthyroidism","status":"COMPLETED","sponsor":"Medical University of Warsaw","startDate":"2015-01-02","conditions":"Hyperthyroidism/Thyrotoxicosis, Hyperthyroidism; Goiter, Iodine Induced Thyrotoxicosis","enrollment":36},{"nctId":"NCT03444246","phase":"NA","title":"A Trial for the Evaluation of the Treatment and Outcome of Hyperthyroidism With Iodized Salt and Non Iodized Salt","status":"UNKNOWN","sponsor":"Xijing Hospital","startDate":"2018-03-01","conditions":"Hyperthyroidism","enrollment":60},{"nctId":"NCT01269749","phase":"PHASE2","title":"Radioactive Iodide Therapy for Pediatric Graves' Disease","status":"COMPLETED","sponsor":"University of Florida","startDate":"2010-10","conditions":"Graves' Disease","enrollment":19},{"nctId":"NCT03066076","phase":"PHASE3","title":"Total Thyroidectomy Versus Thionamides in Patients With Moderate-to-Severe Graves' Ophthalmopathy","status":"UNKNOWN","sponsor":"Medical University of Vienna","startDate":"2017-03-01","conditions":"Graves Disease, Graves Ophthalmopathy, Graves' Ophthalmopathy Worsened","enrollment":60},{"nctId":"NCT01436994","phase":"PHASE3","title":"Antithyroid Drug Treatment of Thyrotoxicosis in Young People","status":"COMPLETED","sponsor":"Newcastle-upon-Tyne Hospitals NHS Trust","startDate":"2004-07","conditions":"Paediatric Thyrotoxicosis","enrollment":81},{"nctId":"NCT01551498","phase":"PHASE2","title":"Evaluating the Dietary Supplement Anatabloc in Thyroid Health-ASAP (Antabloc Supplementation Autoimmune Prevention)","status":"COMPLETED","sponsor":"Rock Creek Pharmaceuticals, Inc.","startDate":"2012-03","conditions":"Thyroiditis, Autoimmune","enrollment":165},{"nctId":"NCT00150124","phase":"PHASE4","title":"Block-replacement Therapy During Radioiodine Therapy","status":"COMPLETED","sponsor":"Steen Bonnema","startDate":"2003-01","conditions":"Toxic Nodular Goitre, Graves' Disease","enrollment":100},{"nctId":"NCT01977963","phase":"","title":"Genetic Study of Antithyroid Drugs Associated Agranulocytosis","status":"UNKNOWN","sponsor":"National Taiwan University Hospital","startDate":"2012-04","conditions":"Agranulocytosis","enrollment":30},{"nctId":"NCT00525122","phase":"","title":"Treatment of M.Graves With Radioactive Iodine: Follow-up Study","status":"UNKNOWN","sponsor":"Medisch Centrum Rijnmond-Zuid, Netherlands","startDate":"2007-09","conditions":"Hyperthyroidism","enrollment":100},{"nctId":"NCT00150137","phase":"PHASE4","title":"Antithyroid Drugs During Radioiodine Therapy","status":"COMPLETED","sponsor":"Odense University Hospital","startDate":"2003-01","conditions":"Toxic Nodular Goitre, Graves Disease","enrollment":80}],"_emaApprovals":[],"_faersSignals":[{"count":2,"reaction":"ALOPECIA"},{"count":2,"reaction":"INAPPROPRIATE SCHEDULE OF DRUG ADMINISTRATION"},{"count":1,"reaction":"ABDOMINAL ABSCESS"},{"count":1,"reaction":"ABNORMAL LOSS OF WEIGHT"},{"count":1,"reaction":"AMENORRHOEA"},{"count":1,"reaction":"APPLICATION SITE PRURITUS"},{"count":1,"reaction":"ARTHROPATHY"},{"count":1,"reaction":"BODY HEIGHT DECREASED"},{"count":1,"reaction":"CEREBROVASCULAR DISORDER"},{"count":1,"reaction":"CONTRAINDICATED DRUG ADMINISTERED"}],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Thiamazol","Propylthiouracil"],"phase":"phase_3","status":"active","brandName":"Antithyroid Drug","genericName":"Antithyroid Drug","companyName":"Seoul St. Mary's Hospital","companyId":"seoul-st-mary-s-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Antithyroid drugs are small molecule medications used to treat conditions such as thyroid dysfunction, hypothyroidism, and hyperthyroidism. They are often used in combination with other treatments, including thyroid hormone replacement therapy like levothyroxine.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}