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Antiseptic substantivity

Universidad de Guanajuato · Phase 3 active Biologic

Antiseptic substantivity refers to the prolonged antimicrobial activity of an antiseptic agent that persists on oral tissues after application.

Antiseptic substantivity refers to the prolonged antimicrobial activity of an antiseptic agent that persists on oral tissues after application. Used for Oral antisepsis with prolonged antimicrobial activity.

At a glance

Generic nameAntiseptic substantivity
Also known as2% chlorhexidine gluconate in 70% isopropyl alcohol (ChloraPrep ®, Enturia, Texas, USA ), hypochlorite 10% of electrochemical production (Except 10% ®, Pisa, Guadalajara, Mexico), 10% povidone-iodine (Isodine Solucion ®, Boehringer-Ingelheim Promeco, Mexico City), Muller Hinton agar plate (BD/BBL ™, México City, México).
SponsorUniversidad de Guanajuato
ModalityBiologic
Therapeutic areaOral Health / Dentistry
PhasePhase 3

Mechanism of action

Substantivity is the ability of an antimicrobial agent to bind to oral tissues and be slowly released over time, maintaining antimicrobial efficacy beyond the initial application period. This property is particularly valuable in oral antiseptics, where prolonged activity can reduce bacterial colonization and biofilm formation on teeth and soft tissues. The mechanism typically involves the agent's affinity for oral mucosa and tooth surfaces, allowing sustained release and extended antimicrobial protection.

Approved indications

Common side effects

No common side effects on file.

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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