{"id":"antiseptic-substantivity","safety":{"commonSideEffects":[]},"_chembl":{"chemblId":"CHEMBL333826","moleculeType":"Small molecule","molecularWeight":"456.68"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Substantivity is the ability of an antimicrobial agent to bind to oral tissues and be slowly released over time, maintaining antimicrobial efficacy beyond the initial application period. This property is particularly valuable in oral antiseptics, where prolonged activity can reduce bacterial colonization and biofilm formation on teeth and soft tissues. The mechanism typically involves the agent's affinity for oral mucosa and tooth surfaces, allowing sustained release and extended antimicrobial protection.","oneSentence":"Antiseptic substantivity refers to the prolonged antimicrobial activity of an antiseptic agent that persists on oral tissues after application.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:01:57.217Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Oral antisepsis with prolonged antimicrobial activity"}]},"trialDetails":[{"nctId":"NCT03174756","phase":"PHASE2","title":"HYPOCHLOROUS ACID SUBSTANTIVITY AS ANTIPLAQUE AGENT (HOCl-SAP)","status":"COMPLETED","sponsor":"Universidad El Bosque, Bogotá","startDate":"2015-01-15","conditions":"Hypochlorous Acid, Mouthwashes","enrollment":75},{"nctId":"NCT01321125","phase":"PHASE3","title":"Chlorhexidine Against Sodium Hypochlorite as Skin Antiseptics","status":"COMPLETED","sponsor":"Universidad de Guanajuato","startDate":"2011-04","conditions":"Infectious Diseases","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":103,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["2% chlorhexidine gluconate in 70% isopropyl alcohol (ChloraPrep ®, Enturia, Texas, USA )","hypochlorite 10% of electrochemical production (Except 10% ®, Pisa, Guadalajara, Mexico)","10% povidone-iodine (Isodine Solucion ®, Boehringer-Ingelheim Promeco, Mexico City)","Muller Hinton agar plate (BD/BBL ™, México City, México)."],"phase":"phase_3","status":"active","brandName":"Antiseptic substantivity","genericName":"Antiseptic substantivity","companyName":"Universidad de Guanajuato","companyId":"universidad-de-guanajuato","modality":"Biologic","firstApprovalDate":"","aiSummary":"Antiseptic substantivity refers to the prolonged antimicrobial activity of an antiseptic agent that persists on oral tissues after application. Used for Oral antisepsis with prolonged antimicrobial activity.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}