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Antibiotic loaded calcium sulfate beads
Antibiotic loaded calcium sulfate beads is a Local antibiotic delivery system Small molecule drug developed by University of Arizona. It is currently FDA-approved for Prevention and treatment of surgical site infections in orthopedic procedures, Osteomyelitis and bone infections, Soft tissue infections associated with surgical wounds.
Calcium sulfate beads loaded with antibiotics provide local, sustained antibiotic delivery directly to surgical sites to prevent or treat bone and soft tissue infections.
Calcium sulfate beads loaded with antibiotics provide local, sustained antibiotic delivery directly to surgical sites to prevent or treat bone and soft tissue infections. Used for Prevention and treatment of surgical site infections in orthopedic procedures, Osteomyelitis and bone infections, Soft tissue infections associated with surgical wounds.
At a glance
| Generic name | Antibiotic loaded calcium sulfate beads |
|---|---|
| Sponsor | University of Arizona |
| Drug class | Local antibiotic delivery system |
| Modality | Small molecule |
| Therapeutic area | Orthopedic Surgery / Infectious Disease |
| Phase | FDA-approved |
Mechanism of action
The calcium sulfate matrix acts as a biodegradable carrier that slowly releases antibiotics (typically vancomycin, tobramycin, or other agents) over weeks at the infection site. As the calcium sulfate resorbs, it is gradually replaced by bone, allowing high local antibiotic concentrations while minimizing systemic exposure and toxicity. This approach is particularly useful in orthopedic and surgical applications where local infection control is critical.
Approved indications
- Prevention and treatment of surgical site infections in orthopedic procedures
- Osteomyelitis and bone infections
- Soft tissue infections associated with surgical wounds
Common side effects
- Local inflammatory response
- Delayed wound healing
- Allergic reaction to antibiotic payload
Key clinical trials
- Local Antibiotic Concentrations With Tissue Expanders in Breast Reconstruction (NA)
- Antibiotic Impregnated Beads in Osteomyelitis (PHASE4)
- Prophylaxis of Periprosthetic Joint Infections With Calcium Sulfate Beads in Patients With Non-modifiable Risk Factors. (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Antibiotic loaded calcium sulfate beads CI brief — competitive landscape report
- Antibiotic loaded calcium sulfate beads updates RSS · CI watch RSS
- University of Arizona portfolio CI
Frequently asked questions about Antibiotic loaded calcium sulfate beads
What is Antibiotic loaded calcium sulfate beads?
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Related
- Drug class: All Local antibiotic delivery system drugs
- Manufacturer: University of Arizona — full pipeline
- Therapeutic area: All drugs in Orthopedic Surgery / Infectious Disease
- Indication: Drugs for Prevention and treatment of surgical site infections in orthopedic procedures
- Indication: Drugs for Osteomyelitis and bone infections
- Indication: Drugs for Soft tissue infections associated with surgical wounds
- Compare: Antibiotic loaded calcium sulfate beads vs similar drugs
- Pricing: Antibiotic loaded calcium sulfate beads cost, discount & access