{"id":"antibiotic-loaded-calcium-sulfate-beads","safety":{"commonSideEffects":[{"rate":null,"effect":"Local inflammatory response"},{"rate":null,"effect":"Delayed wound healing"},{"rate":null,"effect":"Allergic reaction to antibiotic payload"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The calcium sulfate matrix acts as a biodegradable carrier that slowly releases antibiotics (typically vancomycin, tobramycin, or other agents) over weeks at the infection site. As the calcium sulfate resorbs, it is gradually replaced by bone, allowing high local antibiotic concentrations while minimizing systemic exposure and toxicity. This approach is particularly useful in orthopedic and surgical applications where local infection control is critical.","oneSentence":"Calcium sulfate beads loaded with antibiotics provide local, sustained antibiotic delivery directly to surgical sites to prevent or treat bone and soft tissue infections.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:40:42.717Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention and treatment of surgical site infections in orthopedic procedures"},{"name":"Osteomyelitis and bone infections"},{"name":"Soft tissue infections associated with surgical wounds"}]},"trialDetails":[{"nctId":"NCT07339215","phase":"NA","title":"Local Antibiotic Concentrations With Tissue Expanders in Breast Reconstruction","status":"NOT_YET_RECRUITING","sponsor":"University of California, Davis","startDate":"2026-07-01","conditions":"Tissue Expander Based Breast Reconstruction","enrollment":100},{"nctId":"NCT07072923","phase":"PHASE4","title":"Antibiotic Impregnated Beads in Osteomyelitis","status":"NOT_YET_RECRUITING","sponsor":"University of Arizona","startDate":"2025-09-01","conditions":"Osteomyelitis of the Foot, Antibiotic Impregnated Beads, Osteomyelitis of Lower Extremities","enrollment":100},{"nctId":"NCT03976466","phase":"PHASE4","title":"Prophylaxis of Periprosthetic Joint Infections With Calcium Sulfate Beads in Patients With Non-modifiable Risk Factors.","status":"COMPLETED","sponsor":"Hospital Regional Tlalnepantla","startDate":"2019-05-22","conditions":"Infection","enrollment":87}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":19,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Antibiotic loaded calcium sulfate beads","genericName":"Antibiotic loaded calcium sulfate beads","companyName":"University of Arizona","companyId":"university-of-arizona","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Calcium sulfate beads loaded with antibiotics provide local, sustained antibiotic delivery directly to surgical sites to prevent or treat bone and soft tissue infections. Used for Prevention and treatment of surgical site infections in orthopedic procedures, Osteomyelitis and bone infections, Soft tissue infections associated with surgical wounds.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}