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Angal S, topical spray [Menthol]
Menthol produces a cooling sensation by activating TRPM8 cold-sensitive receptors on nerve endings, providing topical analgesic and anti-inflammatory relief.
Menthol produces a cooling sensation by activating TRPM8 cold-sensitive receptors on nerve endings, providing topical analgesic and anti-inflammatory relief. Used for Topical relief of minor muscle and joint pain, Symptomatic relief of minor aches and pains associated with arthritis, backache, and sprains.
At a glance
| Generic name | Angal S, topical spray [Menthol] |
|---|---|
| Sponsor | Sandoz |
| Drug class | Topical analgesic/counterirritant |
| Target | TRPM8 (transient receptor potential melastatin 8) |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | Phase 3 |
Mechanism of action
Menthol is a naturally occurring monoterpene that binds to and activates the transient receptor potential melastatin 8 (TRPM8) channel, a cold-sensing ion channel on sensory nerve fibers. This activation creates a cooling sensation and desensitizes pain pathways through a gate-control mechanism, reducing the perception of pain and providing symptomatic relief of muscle and joint discomfort. The topical spray formulation allows direct application to affected areas for localized therapeutic effect.
Approved indications
- Topical relief of minor muscle and joint pain
- Symptomatic relief of minor aches and pains associated with arthritis, backache, and sprains
Common side effects
- Local skin irritation
- Burning sensation at application site
- Allergic contact dermatitis
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Angal S, topical spray [Menthol] CI brief — competitive landscape report
- Angal S, topical spray [Menthol] updates RSS · CI watch RSS
- Sandoz portfolio CI