{"id":"angal-s-topical-spray-menthol","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation"},{"rate":null,"effect":"Burning sensation at application site"},{"rate":null,"effect":"Allergic contact dermatitis"}]},"_chembl":{"chemblId":"CHEMBL256087","moleculeType":"Small molecule","molecularWeight":"156.27"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Menthol is a naturally occurring monoterpene that binds to and activates the transient receptor potential melastatin 8 (TRPM8) channel, a cold-sensing ion channel on sensory nerve fibers. This activation creates a cooling sensation and desensitizes pain pathways through a gate-control mechanism, reducing the perception of pain and providing symptomatic relief of muscle and joint discomfort. The topical spray formulation allows direct application to affected areas for localized therapeutic effect.","oneSentence":"Menthol produces a cooling sensation by activating TRPM8 cold-sensitive receptors on nerve endings, providing topical analgesic and anti-inflammatory relief.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:01:41.480Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Topical relief of minor muscle and joint pain"},{"name":"Symptomatic relief of minor aches and pains associated with arthritis, backache, and sprains"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Angal S, topical spray [Menthol]","genericName":"Angal S, topical spray [Menthol]","companyName":"Sandoz","companyId":"sandoz","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Menthol produces a cooling sensation by activating TRPM8 cold-sensitive receptors on nerve endings, providing topical analgesic and anti-inflammatory relief. Used for Topical relief of minor muscle and joint pain, Symptomatic relief of minor aches and pains associated with arthritis, backache, and sprains.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}