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Anesthetic Adjuncts
Anesthetic adjuncts are medications used alongside primary anesthetics to enhance anesthesia quality, reduce pain, and improve patient outcomes during surgical procedures.
Anesthetic adjuncts are medications used alongside primary anesthetics to enhance anesthesia quality, reduce pain, and improve patient outcomes during surgical procedures. Used for Adjunctive use in general anesthesia, Perioperative anxiolysis and analgesia, Sedation during surgical procedures.
At a glance
| Generic name | Anesthetic Adjuncts |
|---|---|
| Also known as | opioids, propofol, dexmedetomidine or ketamine |
| Sponsor | Beth Israel Deaconess Medical Center |
| Drug class | Anesthetic adjunct (mixed class) |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Anesthetic adjuncts work through various mechanisms depending on the specific agent—commonly including anxiolysis, analgesia, sedation, or muscle relaxation. They are administered in combination with primary anesthetics (such as propofol or volatile agents) to optimize anesthetic depth, reduce required doses of primary agents, and manage perioperative pain and anxiety. Common adjuncts include opioids, benzodiazepines, alpha-2 agonists, and neuromuscular blocking agents.
Approved indications
- Adjunctive use in general anesthesia
- Perioperative anxiolysis and analgesia
- Sedation during surgical procedures
Common side effects
- Respiratory depression
- Hypotension
- Bradycardia
- Nausea and vomiting
- Delayed emergence from anesthesia
Key clinical trials
- Efficacy of Non-weight Based, Low Dose Dex-Dex Adjuncts in Prolonging Peripheral Nerve Blocks (PHASE1, PHASE2)
- General Anaesthesia vs Spinal Anaesthesia: Patient Outcomes and Success in Outpatient Primary Total Knee and Hip Arthroplasty (PHASE4)
- Comparison of an Inhaled Sedation Strategy to an Intravenous Sedation Strategy in Intensive Care Unit Patients Treated With Invasive Mechanical Ventilation (PHASE3)
- Adjuncts for Adductor Block: Dexamethasone,Dexmedetomidine, or Combination to Reduce Pain (PHASE4)
- Pain Control Following Total Hip Arthroplasty (PHASE1)
- The ALOFT Pilot Trial (NA)
- Avoiding Neuromuscular Blockers to Reduce Complications (PHASE4)
- Wound Infiltration With Tramadol, Dexmedetomidine, or Magnesium Plus Ropivacaine for Pain Relief After Spine Surgery (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Anesthetic Adjuncts CI brief — competitive landscape report
- Anesthetic Adjuncts updates RSS · CI watch RSS
- Beth Israel Deaconess Medical Center portfolio CI