{"id":"anesthetic-adjuncts","safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Delayed emergence from anesthesia"}]},"_chembl":{"chemblId":"CHEMBL596","moleculeType":"Small molecule","molecularWeight":"336.48"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Anesthetic adjuncts work through various mechanisms depending on the specific agent—commonly including anxiolysis, analgesia, sedation, or muscle relaxation. They are administered in combination with primary anesthetics (such as propofol or volatile agents) to optimize anesthetic depth, reduce required doses of primary agents, and manage perioperative pain and anxiety. Common adjuncts include opioids, benzodiazepines, alpha-2 agonists, and neuromuscular blocking agents.","oneSentence":"Anesthetic adjuncts are medications used alongside primary anesthetics to enhance anesthesia quality, reduce pain, and improve patient outcomes during surgical procedures.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:41:48.762Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Adjunctive use in general anesthesia"},{"name":"Perioperative anxiolysis and analgesia"},{"name":"Sedation during surgical procedures"}]},"trialDetails":[{"nctId":"NCT07099222","phase":"PHASE1, PHASE2","title":"Efficacy of Non-weight Based, Low Dose Dex-Dex Adjuncts in Prolonging Peripheral Nerve Blocks","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Arizona","startDate":"2024-10-10","conditions":"Postoperative Pain, Nausea and Vomiting, Postoperative, Dizziness","enrollment":100},{"nctId":"NCT07334132","phase":"PHASE4","title":"General Anaesthesia vs Spinal Anaesthesia: Patient Outcomes and Success in Outpatient Primary Total Knee and Hip Arthroplasty","status":"NOT_YET_RECRUITING","sponsor":"Region Örebro County","startDate":"2026-04-01","conditions":"Osteo Arthritis Knee and Hip, Osteo Arthritis, Inflammatory Joint Disease (IJD)","enrollment":600},{"nctId":"NCT04341350","phase":"PHASE3","title":"Comparison of an Inhaled Sedation Strategy to an Intravenous Sedation Strategy in Intensive Care Unit Patients Treated With Invasive Mechanical Ventilation","status":"RECRUITING","sponsor":"University Hospital, Brest","startDate":"2020-08-06","conditions":"Prevention of Delirium","enrollment":250},{"nctId":"NCT03643822","phase":"PHASE4","title":"Adjuncts for Adductor Block: Dexamethasone,Dexmedetomidine, or Combination to Reduce Pain","status":"RECRUITING","sponsor":"Women's College Hospital","startDate":"2020-02-21","conditions":"ACL Injury","enrollment":252},{"nctId":"NCT05062356","phase":"PHASE1","title":"Pain Control Following Total Hip Arthroplasty","status":"COMPLETED","sponsor":"St. Mary's Research Center, Canada","startDate":"2021-11-04","conditions":"Chronic Postoperative Pain","enrollment":240},{"nctId":"NCT06067789","phase":"NA","title":"The ALOFT Pilot Trial","status":"RECRUITING","sponsor":"Ottawa Hospital Research Institute","startDate":"2024-03-25","conditions":"Vascular Diseases, Peripheral Artery Disease, Surgery","enrollment":90},{"nctId":"NCT03962725","phase":"PHASE4","title":"Avoiding Neuromuscular Blockers to Reduce Complications","status":"TERMINATED","sponsor":"Beth Israel Deaconess Medical Center","startDate":"2019-08-07","conditions":"Respiratory Failure, Respiratory Infection, Aspiration Pneumonia","enrollment":3},{"nctId":"NCT04391855","phase":"PHASE4","title":"Wound Infiltration With Tramadol, Dexmedetomidine, or Magnesium Plus Ropivacaine for Pain Relief After Spine Surgery","status":"COMPLETED","sponsor":"Aristotle University Of Thessaloniki","startDate":"2020-05-10","conditions":"Analgesia, Pain, Postoperative, Spinal Stenosis","enrollment":72},{"nctId":"NCT02653144","phase":"PHASE4","title":"the Analgesic Duration of Dexmedetomidine Compared to Dexamethasone as Adjuncts to Single Shot Interscalene Block","status":"COMPLETED","sponsor":"Montefiore Medical Center","startDate":"2016-03","conditions":"Opioid Use, Unspecified","enrollment":105},{"nctId":"NCT03588689","phase":"PHASE4","title":"Continuous Fascia Iliaca Block for Acute Hip Fractures","status":"COMPLETED","sponsor":"University of Saskatchewan","startDate":"2018-05-07","conditions":"Hip Fractures, Neuromuscular Blockade, Respiratory Morbidity","enrollment":30},{"nctId":"NCT03261921","phase":"PHASE1","title":"Caudal Combination of Dexamethasone and/or Dexmedetomidine to Bupivacaine in Pediatric Hypospadias Surgery","status":"COMPLETED","sponsor":"Cairo University","startDate":"2016-06-05","conditions":"Caudal Block","enrollment":63},{"nctId":"NCT02091297","phase":"NA","title":"Comparison of Different Methods of Pain Control After Cesarean Section for Patients on Buprenorphine or Methadone","status":"WITHDRAWN","sponsor":"Dartmouth-Hitchcock Medical Center","startDate":"2014-04","conditions":"Caesarean Delivery","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":22,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["opioids, propofol, dexmedetomidine or ketamine"],"phase":"marketed","status":"active","brandName":"Anesthetic Adjuncts","genericName":"Anesthetic Adjuncts","companyName":"Beth Israel Deaconess Medical Center","companyId":"beth-israel-deaconess-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Anesthetic adjuncts are medications used alongside primary anesthetics to enhance anesthesia quality, reduce pain, and improve patient outcomes during surgical procedures. Used for Adjunctive use in general anesthesia, Perioperative anxiolysis and analgesia, Sedation during surgical procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}