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Anesthesia maintenance , propofol,remifentanil,cisatracurium
Anesthesia maintenance , propofol,remifentanil,cisatracurium is a General anesthetic combination (GABA-A agonist + opioid + neuromuscular blocker) Small molecule drug developed by Second Affiliated Hospital of Xi'an Jiaotong University. It is currently FDA-approved for Anesthesia maintenance during general surgery, Anesthesia induction and maintenance in intubated patients requiring mechanical ventilation.
This anesthetic regimen combines a GABA-A agonist (propofol), an opioid mu-receptor agonist (remifentanil), and a neuromuscular blocking agent (cisatracurium) to induce unconsciousness, analgesia, and muscle paralysis for surgical procedures.
This anesthetic regimen combines a GABA-A agonist (propofol), an opioid mu-receptor agonist (remifentanil), and a neuromuscular blocking agent (cisatracurium) to induce unconsciousness, analgesia, and muscle paralysis for surgical procedures. Used for Anesthesia maintenance during general surgery, Anesthesia induction and maintenance in intubated patients requiring mechanical ventilation.
At a glance
| Generic name | Anesthesia maintenance , propofol,remifentanil,cisatracurium |
|---|---|
| Sponsor | Second Affiliated Hospital of Xi'an Jiaotong University |
| Drug class | General anesthetic combination (GABA-A agonist + opioid + neuromuscular blocker) |
| Target | GABA-A receptor (propofol); mu-opioid receptor (remifentanil); nicotinic acetylcholine receptor at neuromuscular junction (cisatracurium) |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Propofol enhances inhibitory GABA-A signaling in the central nervous system to produce sedation and hypnosis. Remifentanil activates mu-opioid receptors to provide analgesia and potentiate sedation. Cisatracurium is a non-depolarizing neuromuscular blocker that competitively antagonizes acetylcholine at the neuromuscular junction, producing skeletal muscle paralysis necessary for intubation and mechanical ventilation during surgery.
Approved indications
- Anesthesia maintenance during general surgery
- Anesthesia induction and maintenance in intubated patients requiring mechanical ventilation
Common side effects
- Hypotension
- Bradycardia
- Respiratory depression
- Injection site pain (propofol)
- Postoperative nausea and vomiting
- Muscle rigidity (remifentanil)
Key clinical trials
- Continuous Versus 1-min Oscillometric Arterial BP Monitoring (NA)
- Tubeless Spontaneous Ventilation Anesthesia in Kidney Transplantation (NA)
- Impact of Remimazolam on Prognosis After Bladder Cancer Surgery (PHASE4)
- The Safety of Etomidate - Propofol Mixture vs Propofol in Total Intravenous Anesthesia During Abdominal Surgery (NA)
- Safety of Etomidate-propofol Mixture vs. Propofol for Total Intravenous Anesthesia in Elderly Patients Undergoing Abdominal Surgery (NA)
- REmimazolam vs PrOpofol on Intraoperative hypotenSion in Major Noncardiac surgEry (PHASE4)
- Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair (PHASE4)
- Effect of New High Ankle Block on Wound Healing After the Operation of Debridement of Diabetes Foot (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Anesthesia maintenance , propofol,remifentanil,cisatracurium CI brief — competitive landscape report
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- Second Affiliated Hospital of Xi'an Jiaotong University portfolio CI
Frequently asked questions about Anesthesia maintenance , propofol,remifentanil,cisatracurium
What is Anesthesia maintenance , propofol,remifentanil,cisatracurium?
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Related
- Drug class: All General anesthetic combination (GABA-A agonist + opioid + neuromuscular blocker) drugs
- Target: All drugs targeting GABA-A receptor (propofol); mu-opioid receptor (remifentanil); nicotinic acetylcholine receptor at neuromuscular junction (cisatracurium)
- Manufacturer: Second Affiliated Hospital of Xi'an Jiaotong University — full pipeline
- Therapeutic area: All drugs in Anesthesiology
- Indication: Drugs for Anesthesia maintenance during general surgery
- Indication: Drugs for Anesthesia induction and maintenance in intubated patients requiring mechanical ventilation
- Compare: Anesthesia maintenance , propofol,remifentanil,cisatracurium vs similar drugs
- Pricing: Anesthesia maintenance , propofol,remifentanil,cisatracurium cost, discount & access