{"id":"anesthesia-maintenance-propofol-remifentanil-cisatracurium","safety":{"commonSideEffects":[{"rate":"20-30","effect":"Hypotension"},{"rate":"10-20","effect":"Bradycardia"},{"rate":"variable with mechanical ventilation","effect":"Respiratory depression"},{"rate":"10-15","effect":"Injection site pain (propofol)"},{"rate":"10-30","effect":"Postoperative nausea and vomiting"},{"rate":"5-10","effect":"Muscle rigidity (remifentanil)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Propofol enhances inhibitory GABA-A signaling in the central nervous system to produce sedation and hypnosis. Remifentanil activates mu-opioid receptors to provide analgesia and potentiate sedation. Cisatracurium is a non-depolarizing neuromuscular blocker that competitively antagonizes acetylcholine at the neuromuscular junction, producing skeletal muscle paralysis necessary for intubation and mechanical ventilation during surgery.","oneSentence":"This anesthetic regimen combines a GABA-A agonist (propofol), an opioid mu-receptor agonist (remifentanil), and a neuromuscular blocking agent (cisatracurium) to induce unconsciousness, analgesia, and muscle paralysis for surgical procedures.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:42:27.727Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Anesthesia maintenance during general surgery"},{"name":"Anesthesia induction and maintenance in intubated patients requiring mechanical ventilation"}]},"trialDetails":[{"nctId":"NCT05792436","phase":"NA","title":"Continuous Versus 1-min Oscillometric Arterial BP Monitoring","status":"COMPLETED","sponsor":"Seoul National University 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(remifentanil), and a neuromuscular blocking agent (cisatracurium) to induce unconsciousness, analgesia, and muscle paralysis for surgical procedures. Used for Anesthesia maintenance during general surgery, Anesthesia induction and maintenance in intubated patients requiring mechanical ventilation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}