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Nitramyl (Amyl Nitrite)
Nitramyl works by rapidly converting cyanide into a less toxic compound through a process called cytochrome c oxidase inhibition.
Nitramyl (Amyl Nitrite) is a small molecule drug in the amyl nitrite class, originally developed by Johns Hopkins University and currently owned by the same institution. It is used to treat the toxic effects of cyanide. The commercial status of Nitramyl is unclear, and it is not known whether it is patented or available as a generic. Key safety considerations include its potential for adverse effects, although specific details are not available. Further research is needed to fully understand its pharmacological properties.
At a glance
| Generic name | Amyl Nitrite |
|---|---|
| Sponsor | Johns Hopkins University |
| Drug class | amyl nitrite |
| Modality | Small molecule |
| Therapeutic area | Respiratory |
| Phase | discontinued |
Mechanism of action
Imagine your body's cells are like factories that use oxygen to make energy. Cyanide is like a poison that stops these factories from working. Nitramyl helps by converting the cyanide into a harmless compound, allowing the factories to start working again.
Approved indications
- Toxic effect of cyanide
Common side effects
- Methemoglobinemia
- Syncope
- Involuntary passing of urine and feces
- Hypotension
- Pallor
- Cold sweat
- Tachycardia
- Restlessness
- Weakness
- Vomiting
- Nausea
Key clinical trials
- Comparison of Squat-to-Stand Maneuver With Amyl Nitrite, Valsalva, and Exercise Stress Echocardiography in Inducing Latent Left Ventricular Outflow Obstruction in Hypertrophic Cardiomyopathy (NA)
- Diagnostic Utility of Amyl Nitrite in Patients With Suspected Achalasia Undergoing High Resolution Esophageal Manometry (HREM) (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Nitramyl CI brief — competitive landscape report
- Nitramyl updates RSS · CI watch RSS
- Johns Hopkins University portfolio CI