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American Ginseng root
American Ginseng root is a Herbal supplement / Adaptogen Small molecule drug developed by Southern Illinois University. It is currently FDA-approved for Fatigue and energy enhancement, Immune system support, Stress and anxiety reduction. Also known as: LEAG, Ginseng.
American Ginseng root contains bioactive compounds (ginsenosides) that modulate immune function, reduce inflammation, and enhance stress resilience through multiple signaling pathways.
American Ginseng root, also known as Panax quinquefolius L, has been studied in clinical trials for its potential effects on cognitive performance, including conditions such as reaction time, memory, learning, attention, and cognition. The exact mechanism of action of American Ginseng root is currently unknown.
At a glance
| Generic name | American Ginseng root |
|---|---|
| Also known as | LEAG, Ginseng |
| Sponsor | Southern Illinois University |
| Drug class | Herbal supplement / Adaptogen |
| Modality | Small molecule |
| Therapeutic area | Immunology / General wellness |
| Phase | FDA-approved |
Mechanism of action
American Ginseng (Panax quinquefolius) contains ginsenosides and polysaccharides that act as immunomodulators and adaptogenic agents. These compounds influence cytokine production, enhance natural killer cell activity, and may improve glucose metabolism and antioxidant defenses. The root has been traditionally used and studied for its ability to improve energy, reduce fatigue, and support overall physiological resilience.
Approved indications
- Fatigue and energy enhancement
- Immune system support
- Stress and anxiety reduction
- Blood glucose regulation support
Common side effects
- Insomnia or sleep disturbance
- Headache
- Gastrointestinal upset
- Nervousness or agitation
Key clinical trials
- Wisconsin Ginseng for Decreasing Cancer Related Fatigue (PHASE3)
- Cereboost (American Ginseng Extract) and Brain Function (NA)
- LCMS-Based Metabolic Analysis Explores the Effect of American Ginseng on Urine and Plasma in Healthy Individuals (NA)
- Evaluation of the Impact of Taking American Ginseng for 8 Weeks on Fatigue in Patients Treated for Localized Breast or Gynecological Cancer (NA)
- Efficacy of Ginseng for Patients on Regorafenib (PHASE2)
- An Exploratory Investigation of a Supplement to Promote Brain Health (NA)
- The Acute Effects of a Dietary Supplement on Cognitive Performance in Highly Trained Athletes. (NA)
- The Efficacy and Safety of a Chinese Herbal Medicine for Long COVID Associated Fatigue (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- American Ginseng root CI brief — competitive landscape report
- American Ginseng root updates RSS · CI watch RSS
- Southern Illinois University portfolio CI
Frequently asked questions about American Ginseng root
What is American Ginseng root?
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What drug class is American Ginseng root in?
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Related
- Drug class: All Herbal supplement / Adaptogen drugs
- Manufacturer: Southern Illinois University — full pipeline
- Therapeutic area: All drugs in Immunology / General wellness
- Indication: Drugs for Fatigue and energy enhancement
- Indication: Drugs for Immune system support
- Indication: Drugs for Stress and anxiety reduction
- Also known as: LEAG, Ginseng
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing