{"id":"american-ginseng-root","safety":{"commonSideEffects":[{"rate":null,"effect":"Insomnia or sleep disturbance"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Nervousness or agitation"}]},"_chembl":{"chemblId":"CHEMBL2109196","moleculeType":"Unknown"},"_dailymed":{"setId":"e5bbe9ec-7602-4de5-907a-7047c10198b6","title":"CENTROCODE (AMERICAN GINSENG, ADENOSINE TRIPHOSPHATE, CORTICOTROPIN, ALFALFA, BOS TAURUS HYPOTHALAMUS, PHYTOLACCA AMERICANA ROOT, BOS TAURUS PITUITARY GLAND POSTERIOR, THYROID UNSPECIFIED, IODINE, SILICON DIOXIDE, OSTER SHELL CALCIUM CARBONATE CRUDE, STRYCHNOS IGNATII SEED, IRIDIUM, LACHESIS MUTA VENOM, LYCOPODIUM CLAVATUM SPORE, SODIUM CHLORIDE, STRYCHNOS NUX-VOMICA SEED, PHOSPHORUS, SELENIUM, URANYL NITRATE HEXAHYDRATE.) LIQUID [NATURAL CREATIONS, INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"American Ginseng (Panax quinquefolius) contains ginsenosides and polysaccharides that act as immunomodulators and adaptogenic agents. These compounds influence cytokine production, enhance natural killer cell activity, and may improve glucose metabolism and antioxidant defenses. The root has been traditionally used and studied for its ability to improve energy, reduce fatigue, and support overall physiological resilience.","oneSentence":"American Ginseng root contains bioactive compounds (ginsenosides) that modulate immune function, reduce inflammation, and enhance stress resilience through multiple signaling pathways.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T04:08:39.916Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Fatigue and energy enhancement"},{"name":"Immune system support"},{"name":"Stress and anxiety reduction"},{"name":"Blood glucose regulation support"}]},"trialDetails":[{"nctId":"NCT06395441","phase":"PHASE3","title":"Wisconsin Ginseng for Decreasing Cancer Related Fatigue","status":"RECRUITING","sponsor":"Mayo Clinic","startDate":"2024-08-01","conditions":"Malignant Solid Neoplasm","enrollment":160},{"nctId":"NCT07255755","phase":"NA","title":"Cereboost (American Ginseng Extract) and Brain Function","status":"RECRUITING","sponsor":"University of East Anglia","startDate":"2025-12-01","conditions":"Attention, Cognition","enrollment":200},{"nctId":"NCT07252362","phase":"NA","title":"LCMS-Based Metabolic Analysis Explores the Effect of American Ginseng on Urine and Plasma in Healthy Individuals","status":"RECRUITING","sponsor":"Zhejiang Cancer Hospital","startDate":"2023-11-11","conditions":"The Impact of American Ginseng on the Metabolomics of Urine and Plasma in Healthy Individuals","enrollment":20},{"nctId":"NCT05241405","phase":"NA","title":"Evaluation of the Impact of Taking American Ginseng for 8 Weeks on Fatigue in Patients Treated for Localized Breast or Gynecological Cancer","status":"RECRUITING","sponsor":"Centre Francois Baclesse","startDate":"2022-09-27","conditions":"Breast Cancer, Fatigue","enrollment":354},{"nctId":"NCT02581059","phase":"PHASE2","title":"Efficacy of Ginseng for Patients on Regorafenib","status":"TERMINATED","sponsor":"Wake Forest University 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Chinese Medicine Formula （Shen Qi Tiao Ti Formula） Intervention to Polycystic Ovary Syndrome","status":"UNKNOWN","sponsor":"Heilongjiang University of Chinese Medicine","startDate":"2018-08-10","conditions":"Polycystic Ovary Syndrome","enrollment":105},{"nctId":"NCT03479294","phase":"","title":"Real-World Study on Adjuvant Therapy Combined With Shenlingcao Oral Liquid in Patients for Stage II and IIIA Non-small Cell Lung Cancer After Radical Resection","status":"TERMINATED","sponsor":"West China Hospital","startDate":"2018-03-28","conditions":"Carcinoma, Non-Small-Cell Lung, Chemotherapy, Adjuvant","enrollment":9},{"nctId":"NCT03579095","phase":"NA","title":"Investigating the Acute and Chronic Effects of an American Ginseng Root Extract on Cognition and Mood","status":"COMPLETED","sponsor":"University of Reading","startDate":"2018-05-04","conditions":"Cognitive Change, Effects of Ginseng on Cognitive Function","enrollment":60},{"nctId":"NCT03730298","phase":"NA","title":"American Ginseng for the Prevention of Moderate-severe Fatigue in Breast Cancer Patients","status":"UNKNOWN","sponsor":"Network Italiano Cure di Supporto in Oncologia","startDate":"2018-11-29","conditions":"Cancer Related Fatigue, Breast Cancer Female","enrollment":290},{"nctId":"NCT01578837","phase":"PHASE1, PHASE2","title":"Combined Rg3-enriched Korean Red Ginseng and American Ginseng in the Management of Hypertension in Type 2 Diabetes","status":"COMPLETED","sponsor":"Unity Health Toronto","startDate":"2014-04","conditions":"Diabetes Mellitus Type 2, Hypertension","enrollment":90},{"nctId":"NCT01500096","phase":"PHASE2","title":"American Ginseng to Improve HIV-Associated Fatigue: A Randomized, Placebo-Controlled, Parallel Design, Multiple-Dose Clinical Trial","status":"COMPLETED","sponsor":"Johns Hopkins University","startDate":"2013-02","conditions":"HIV/AIDS-associated Fatigue","enrollment":96},{"nctId":"NCT01136928","phase":"PHASE1","title":"Pharmacokinetic Interaction Study of Efavirenz and American Ginseng in Healthy Volunteers","status":"COMPLETED","sponsor":"Johns Hopkins University","startDate":"2010-09-28","conditions":"Healthy Volunteers","enrollment":15},{"nctId":"NCT00182780","phase":"NA","title":"American Ginseng in Treating Patients With Cancer-Related Fatigue","status":"COMPLETED","sponsor":"Alliance for Clinical Trials in Oncology","startDate":"2005-10","conditions":"Fatigue, Unspecified Adult Solid Tumor, Protocol Specific","enrollment":290},{"nctId":"NCT00719563","phase":"PHASE3","title":"American Ginseng in Treating Patients With Fatigue Caused by Cancer","status":"COMPLETED","sponsor":"Alliance for Clinical Trials in Oncology","startDate":"2008-10","conditions":"Chronic Myeloproliferative Disorders, Fatigue, Leukemia","enrollment":364},{"nctId":"NCT02923453","phase":"PHASE2","title":"Effect of Ginseng in Type 2 Diabetes","status":"COMPLETED","sponsor":"Unity Health Toronto","startDate":"1998-03","conditions":"Type II Diabetes Control","enrollment":23},{"nctId":"NCT02806349","phase":"PHASE2","title":"Konjac-Glucomannan Fibre Blend and American Ginseng in Type 2 Diabetes","status":"COMPLETED","sponsor":"Vladimir Vuksan","startDate":"2002-03","conditions":"Diabetes Mellitus, Type 2","enrollment":39},{"nctId":"NCT01827696","phase":"PHASE1","title":"Effect of American Ginseng on Exercise-induced Muscle Soreness","status":"COMPLETED","sponsor":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","startDate":"2013-05","conditions":"Muscle Damage","enrollment":10},{"nctId":"NCT00728403","phase":"PHASE2","title":"Metabolic and Therapeutic Effects of American and Korean Red Ginseng in the Treatment of Type 2 Diabetes","status":"UNKNOWN","sponsor":"Unity Health Toronto","startDate":"2008-09","conditions":"Diabetes Mellitus Type 2","enrollment":120},{"nctId":"NCT00965822","phase":"PHASE2","title":"A Randomized, Double-blind, Placebo-controlled Study on the Efficacy and Safety of CVT-E002 in the Treatment of Upper Respiratory Tract Infections in a Pediatric (3-11 Years) Population","status":"COMPLETED","sponsor":"Afexa Life Sciences Inc","startDate":"2009-09","conditions":"Upper Respiratory Tract Infections","enrollment":293},{"nctId":"NCT00754832","phase":"PHASE2","title":"American Ginseng Treatment for Multiple Sclerosis Related Fatigue","status":"COMPLETED","sponsor":"Oregon Health and Science University","startDate":"2005-09","conditions":"Multiple Sclerosis","enrollment":56},{"nctId":"NCT00527969","phase":"PHASE2","title":"Cognitive, Emotional, Physical and Psychosocial Effects of Panax Quinquefolius L","status":"COMPLETED","sponsor":"CV Technologies","startDate":"2007-07","conditions":"Memory, Learning, Attention","enrollment":72},{"nctId":"NCT00255307","phase":"PHASE2","title":"Pilot Evaluation of CVT-E002 in Pediatric Upper Respiratory Tract Infection.","status":"COMPLETED","sponsor":"CV Technologies","startDate":"2005-11","conditions":"Upper Respiratory Infection","enrollment":75},{"nctId":"NCT00367926","phase":"PHASE3","title":"The Effect of American Ginseng Root and Its Components on Glycemia in Healthy Individuals","status":"COMPLETED","sponsor":"Risk Factor Modification Centre","startDate":"2005-06","conditions":"Hyperglycemia","enrollment":12},{"nctId":"NCT00219960","phase":"PHASE3","title":"The Effect of North American Ginseng on Blood Pressure in Individuals With Hypertension","status":"COMPLETED","sponsor":"Risk Factor Modification Centre","startDate":"2001-04","conditions":"Hypertension","enrollment":52}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":39,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["LEAG","Ginseng"],"phase":"marketed","status":"active","brandName":"American Ginseng root","genericName":"American Ginseng root","companyName":"Southern Illinois University","companyId":"southern-illinois-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"American Ginseng root, also known as Panax quinquefolius L, has been studied in clinical trials for its potential effects on cognitive performance, including conditions such as reaction time, memory, learning, attention, and cognition. The exact mechanism of action of American Ginseng root is currently unknown.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}