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alverine citrate and simeticone
Alverine citrate is a smooth muscle relaxant that reduces intestinal spasms, while simeticone is an anti-foaming agent that reduces gas bloating.
Alverine citrate is a smooth muscle relaxant that reduces intestinal spasms, while simeticone is an anti-foaming agent that reduces gas bloating. Used for Irritable bowel syndrome (IBS) with abdominal pain and bloating, Functional gastrointestinal disorders with spasm and gas distension.
At a glance
| Generic name | alverine citrate and simeticone |
|---|---|
| Also known as | Meteospasmyl® |
| Sponsor | Laboratoires Mayoly Spindler |
| Drug class | Antispasmodic/anti-foaming combination |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology |
| Phase | FDA-approved |
Mechanism of action
Alverine citrate works as a direct-acting smooth muscle relaxant on the gastrointestinal tract, reducing painful spasms and cramping. Simeticone is a silicone-based anti-foaming agent that breaks down gas bubbles in the intestines, reducing bloating and discomfort. Together, they provide symptomatic relief of functional gastrointestinal disorders.
Approved indications
- Irritable bowel syndrome (IBS) with abdominal pain and bloating
- Functional gastrointestinal disorders with spasm and gas distension
Common side effects
- Headache
- Dizziness
- Gastrointestinal upset
- Rash
Key clinical trials
- Carvedilol and Alverine in Portal Hypertension (PHASE2, PHASE3)
- The Safety and Efficacy of Alverine in the Treatment of Cirrhotic Portal Hypertension (PHASE2, PHASE3)
- The Efficacy and Safety of Alverine in the Treatment of Portal Hypertension in Patients With Liver Cirrhosis (PHASE2, PHASE3)
- The Role of Irritable Bowel Syndrome in Lactose Intolerance (LION) (NA)
- Combination of Alverine-simeticone and i3.1 Probiotic in IBS-D and IBS-M in Mexico (PHASE4)
- Effectiveness of On-demand Meteospasmyl® Use in Irritable Bowel Syndrome (IBS) (PHASE4)
- Efficacy and Safety of Meteospasmyl® in Irritable Bowel Syndrome (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- alverine citrate and simeticone CI brief — competitive landscape report
- alverine citrate and simeticone updates RSS · CI watch RSS
- Laboratoires Mayoly Spindler portfolio CI