{"id":"alverine-citrate-and-simeticone","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Rash"}]},"_chembl":{"chemblId":"CHEMBL1408594","moleculeType":"Small molecule","molecularWeight":"473.57"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Alverine citrate works as a direct-acting smooth muscle relaxant on the gastrointestinal tract, reducing painful spasms and cramping. Simeticone is a silicone-based anti-foaming agent that breaks down gas bubbles in the intestines, reducing bloating and discomfort. Together, they provide symptomatic relief of functional gastrointestinal disorders.","oneSentence":"Alverine citrate is a smooth muscle relaxant that reduces intestinal spasms, while simeticone is an anti-foaming agent that reduces gas bloating.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:42:13.059Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Irritable bowel syndrome (IBS) with abdominal pain and bloating"},{"name":"Functional gastrointestinal disorders with spasm and gas distension"}]},"trialDetails":[{"nctId":"NCT06696248","phase":"PHASE2, PHASE3","title":"Carvedilol and Alverine in Portal Hypertension","status":"NOT_YET_RECRUITING","sponsor":"Shanghai Changzheng Hospital","startDate":"2024-11-15","conditions":"Hypertension, Portal","enrollment":30},{"nctId":"NCT06473493","phase":"PHASE2, PHASE3","title":"The Safety and Efficacy of Alverine in the Treatment of Cirrhotic Portal Hypertension","status":"NOT_YET_RECRUITING","sponsor":"Shanghai Changzheng Hospital","startDate":"2024-06","conditions":"Hypertension, Portal","enrollment":30},{"nctId":"NCT06470386","phase":"PHASE2, PHASE3","title":"The Efficacy and Safety of Alverine in the Treatment of Portal Hypertension in Patients With Liver Cirrhosis","status":"NOT_YET_RECRUITING","sponsor":"Shanghai Changzheng Hospital","startDate":"2024-06","conditions":"Hypertension, Portal","enrollment":178},{"nctId":"NCT05100719","phase":"NA","title":"The Role of Irritable Bowel Syndrome in Lactose Intolerance (LION)","status":"NOT_YET_RECRUITING","sponsor":"University of Pecs","startDate":"2022-09","conditions":"Irritable Bowel Syndrome, Lactose Intolerance, Lactose Malabsorption","enrollment":200},{"nctId":"NCT04145856","phase":"PHASE4","title":"Combination of Alverine-simeticone and i3.1 Probiotic in IBS-D and IBS-M in Mexico","status":"COMPLETED","sponsor":"Hospital Juarez de Mexico","startDate":"2018-09-03","conditions":"Irritable Bowel Syndrome","enrollment":55},{"nctId":"NCT01404923","phase":"PHASE4","title":"Effectiveness of On-demand Meteospasmyl® Use in Irritable Bowel Syndrome (IBS)","status":"COMPLETED","sponsor":"Laboratoires Mayoly Spindler","startDate":"2009-12","conditions":"Irritable Bowel Syndrome","enrollment":436},{"nctId":"NCT00542295","phase":"PHASE4","title":"Efficacy and Safety of Meteospasmyl® in Irritable Bowel Syndrome","status":"COMPLETED","sponsor":"Laboratoires Mayoly Spindler","startDate":"2007-07","conditions":"Irritable Bowel Syndrome","enrollment":400}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Meteospasmyl®"],"phase":"marketed","status":"active","brandName":"alverine citrate and simeticone","genericName":"alverine citrate and simeticone","companyName":"Laboratoires Mayoly Spindler","companyId":"laboratoires-mayoly-spindler","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Alverine citrate is a smooth muscle relaxant that reduces intestinal spasms, while simeticone is an anti-foaming agent that reduces gas bloating. Used for Irritable bowel syndrome (IBS) with abdominal pain and bloating, Functional gastrointestinal disorders with spasm and gas distension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}