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Alternating Acetaminophen and Ibuprofen
Alternating acetaminophen and ibuprofen provides complementary analgesic and anti-inflammatory effects by sequentially blocking different pain and fever pathways.
Alternating acetaminophen and ibuprofen provides complementary analgesic and anti-inflammatory effects by sequentially blocking different pain and fever pathways. Used for Acute pain management (Phase 3 investigational).
At a glance
| Generic name | Alternating Acetaminophen and Ibuprofen |
|---|---|
| Also known as | Alternating regimen |
| Sponsor | Washington University School of Medicine |
| Drug class | Analgesic combination therapy |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | Phase 3 |
Mechanism of action
Acetaminophen inhibits prostaglandin synthesis primarily in the central nervous system, reducing pain and fever perception. Ibuprofen is a non-selective COX inhibitor that reduces prostaglandin production peripherally and centrally, providing anti-inflammatory and analgesic effects. By alternating these agents, the regimen aims to optimize pain control while potentially reducing individual drug exposure and associated adverse effects.
Approved indications
- Acute pain management (Phase 3 investigational)
Common side effects
- Gastrointestinal upset
- Hepatotoxicity (acetaminophen)
- Renal impairment (ibuprofen)
- Nausea
Key clinical trials
- The Effect of Multimodal Pain Regimen on Use of Narcotics After Rotator Cuff Tear Repair (PHASE4)
- Meloxicam in Mohs Micrographic Surgery (PHASE4)
- Muscle Relaxation for Pediatric Adenotonsillectomy (PHASE4)
- Management of Postoperative Discomfort in Young Children Following Dental Rehabilitation Under General Anesthesia (PHASE4)
- Comparing the Difference in Pain Control in the Pediatric General Surgery Population: to Alternate or Combine Acetaminophen and Ibuprofen? (PHASE4)
- Management of Post-Tonsillectomy Pain in Pediatric Patients (PHASE3)
- Enhanced Recovery After Bilateral Reduction Mammaplasty (NA)
- Effect of Post-operative Ibuprofen After Surgery for Chronic Rhinosinusitis (PHASE2, PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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