{"id":"alternating-acetaminophen-and-ibuprofen","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Hepatotoxicity (acetaminophen)"},{"rate":null,"effect":"Renal impairment (ibuprofen)"},{"rate":null,"effect":"Nausea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Acetaminophen inhibits prostaglandin synthesis primarily in the central nervous system, reducing pain and fever perception. Ibuprofen is a non-selective COX inhibitor that reduces prostaglandin production peripherally and centrally, providing anti-inflammatory and analgesic effects. By alternating these agents, the regimen aims to optimize pain control while potentially reducing individual drug exposure and associated adverse effects.","oneSentence":"Alternating acetaminophen and ibuprofen provides complementary analgesic and anti-inflammatory effects by sequentially blocking different pain and fever pathways.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:01:04.345Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute pain management (Phase 3 investigational)"}]},"trialDetails":[{"nctId":"NCT07076069","phase":"PHASE4","title":"The Effect of Multimodal Pain Regimen on Use of Narcotics After Rotator Cuff Tear Repair","status":"RECRUITING","sponsor":"Montefiore Medical Center","startDate":"2025-07-21","conditions":"Rotator Cuff Repairs, Pain Management","enrollment":130},{"nctId":"NCT07200544","phase":"PHASE4","title":"Meloxicam in Mohs Micrographic Surgery","status":"RECRUITING","sponsor":"University of 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