Last reviewed 2026-04-22 · How we verify

Alphalipoic acid

Alpha-lipoic acid is a mitochondrial cofactor that acts as a potent antioxidant and free radical scavenger, reducing oxidative stress in cells.

Alpha-lipoic acid is a mitochondrial cofactor that acts as a potent antioxidant and free radical scavenger, reducing oxidative stress in cells. Used for Diabetic peripheral neuropathy, Diabetic autonomic neuropathy, Age-related cognitive decline.

At a glance

Mechanism of action

Alpha-lipoic acid (ALA) is a naturally occurring compound that functions as a coenzyme in mitochondrial energy metabolism and possesses both lipophilic and hydrophilic antioxidant properties. It scavenges reactive oxygen species and regenerates other antioxidants such as vitamins C and E, thereby reducing cellular oxidative damage. ALA also modulates inflammatory pathways and may improve mitochondrial function, making it useful in conditions characterized by oxidative stress and metabolic dysfunction.

Approved indications

• Diabetic peripheral neuropathy
• Diabetic autonomic neuropathy
• Age-related cognitive decline
• Metabolic syndrome

Common side effects

• Nausea
• Abdominal discomfort
• Headache
• Dizziness
• Rash

Key clinical trials

• Effect of Alpha Lipoic Acid on Non-alcoholic Fatty Liver Diseases (PHASE4)
• Metabolic and Clinical Effect of Alpha-lipoic Acid Administration in Schizophrenic Subjects (NA)
• Evaluate the Improving Effects of Visucomplex Plus on Quality of Life in Patients With AMD

Primary sources

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Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• Alphalipoic acid CI brief — competitive landscape report
• Alphalipoic acid updates RSS · CI watch RSS
• All India Institute of Medical Sciences, Bhubaneswar portfolio CI