{"id":"alphalipoic-acid","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Abdominal discomfort"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Rash"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Alpha-lipoic acid (ALA) is a naturally occurring compound that functions as a coenzyme in mitochondrial energy metabolism and possesses both lipophilic and hydrophilic antioxidant properties. It scavenges reactive oxygen species and regenerates other antioxidants such as vitamins C and E, thereby reducing cellular oxidative damage. ALA also modulates inflammatory pathways and may improve mitochondrial function, making it useful in conditions characterized by oxidative stress and metabolic dysfunction.","oneSentence":"Alpha-lipoic acid is a mitochondrial cofactor that acts as a potent antioxidant and free radical scavenger, reducing oxidative stress in cells.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:27:00.949Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Diabetic peripheral neuropathy"},{"name":"Diabetic autonomic neuropathy"},{"name":"Age-related cognitive decline"},{"name":"Metabolic syndrome"}]},"trialDetails":[{"nctId":"NCT04475276","phase":"PHASE4","title":"Effect of Alpha Lipoic Acid on Non-alcoholic Fatty Liver Diseases","status":"COMPLETED","sponsor":"All India Institute of Medical Sciences, Bhubaneswar","startDate":"2021-02-23","conditions":"Non-Alcoholic Fatty Liver Disease","enrollment":120},{"nctId":"NCT06787781","phase":"NA","title":"Metabolic and Clinical Effect of Alpha-lipoic Acid Administration in Schizophrenic Subjects","status":"COMPLETED","sponsor":"University of Messina","startDate":"2021-06-01","conditions":"Metabolic Evaluation, Cardiac Complications","enrollment":15},{"nctId":"NCT04177069","phase":"","title":"Evaluate the Improving Effects of Visucomplex Plus on Quality of Life in Patients With AMD","status":"UNKNOWN","sponsor":"VISUfarma SpA","startDate":"2019-12-11","conditions":"AMD","enrollment":160}],"_emaApprovals":[],"_faersSignals":[{"count":4,"reaction":"DIZZINESS"},{"count":4,"reaction":"INSOMNIA"},{"count":3,"reaction":"BLOOD PRESSURE INCREASED"},{"count":3,"reaction":"FLUSHING"},{"count":3,"reaction":"HEADACHE"},{"count":3,"reaction":"NAUSEA"},{"count":3,"reaction":"NEUROPATHY PERIPHERAL"},{"count":3,"reaction":"PAIN IN EXTREMITY"},{"count":2,"reaction":"ARTHRALGIA"},{"count":2,"reaction":"ASTHENIA"}],"_approvalHistory":[],"publicationCount":9,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Alphalipoic acid","genericName":"Alphalipoic acid","companyName":"All India Institute of Medical Sciences, Bhubaneswar","companyId":"all-india-institute-of-medical-sciences-bhubaneswar","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Alpha-lipoic acid is a mitochondrial cofactor that acts as a potent antioxidant and free radical scavenger, reducing oxidative stress in cells. Used for Diabetic peripheral neuropathy, Diabetic autonomic neuropathy, Age-related cognitive decline.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}